M
Mark Urnes
Researcher at Bristol-Myers Squibb
Publications - 2
Citations - 1902
Mark Urnes is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: T cell & CD3. The author has an hindex of 2, co-authored 2 publications receiving 1844 citations.
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CTLA-4 is a second receptor for the B cell activation antigen B7.
Peter S. Linsley,William E. Brady,Mark Urnes,Laura Sue Grosmaire,Nitin K. Damle,Jeffrey A. Ledbetter +5 more
TL;DR: These findings provide direct evidence that, like its structural homologue CD28, CTLA- 4 is able to bind the B7 counter-receptor on activated B cells.
Journal Article
CD28 engagement by B7/BB-1 induces transient down-regulation of CD28 synthesis and prolonged unresponsiveness to CD28 signaling
TL;DR: It is shown that CD28 expression and signaling activity in activated T cells decrease after ligand binding to CD28, which represents a novel mechanism for regulation of costimulatory signals delivered by interactions of CD28 with the B7/BB-1 counter receptor.