M
Markus Bischoff
Researcher at Saarland University
Publications - 156
Citations - 5658
Markus Bischoff is an academic researcher from Saarland University. The author has contributed to research in topics: Staphylococcus aureus & Virulence. The author has an hindex of 42, co-authored 145 publications receiving 4879 citations. Previous affiliations of Markus Bischoff include University of Zurich & ETH Zurich.
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Journal ArticleDOI
Microarray-based analysis of the Staphylococcus aureus sigmaB regulon.
Markus Bischoff,Paul M. Dunman,Jan Kormanec,D. Macapagal,Ellen Murphy,William Mounts,Brigitte Berger-Bächi,Steven J. Projan +7 more
TL;DR: The data presented here suggest that the σB of S. aureus controls a large regulon and is an important modulator of virulence gene expression that is likely to act conversely to RNAIII, the effector molecule of the agr locus.
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Sigma(B) activity depends on RsbU in Staphylococcus aureus
TL;DR: In GP268, the heat inducibility of sigma(B)-dependent genes, Asp23 production, alpha-hemolysin activity, pigmentation, and susceptibility to H2O2 were restored to the levels observed in strain Newman, clearly demonstrating that RsbU is needed for activation of s Sigma(B) in S. aureus.
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Influence of a Functional sigB Operon on the Global Regulators sar and agr in Staphylococcus aureus
TL;DR: The data presented here suggest that sigma(B) increases sar expression while simultaneously reducing the RNAIII level in a growth phase-dependent manner.
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Staphylococcus aureus CcpA Affects Virulence Determinant Production and Antibiotic Resistance
Kati Seidl,Martin Stucki,Martin Kaspar Rüegg,Christiane Goerke,Christiane Wolz,Llinos G. Harris,Brigitte Berger-Bächi,Markus Bischoff +7 more
TL;DR: The staphylococcal CcpA thus not only is involved in the regulation of carbon metabolism but seems to function as a modulator of virulence gene expression as well.
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Staphylococcus aureus CcpA Affects Biofilm Formation
Kati Seidl,Christiane Goerke,Christiane Wolz,Dietrich Mack,Brigitte Berger-Bächi,Markus Bischoff,Markus Bischoff +6 more
TL;DR: Investigation of several factors reported to influence biofilm formation in S. aureus showed that CcpA up-regulated the transcription of cidA, which was recently shown to contribute to eDNA production, and increased icaA expression and PIA production, presumably over the down-regulation of the tricarboxylic acid cycle genes citB and citZ.