S
Steven J. Projan
Researcher at Public Health Research Institute
Publications - 86
Citations - 11374
Steven J. Projan is an academic researcher from Public Health Research Institute. The author has contributed to research in topics: Plasmid & Gene. The author has an hindex of 53, co-authored 86 publications receiving 10741 citations. Previous affiliations of Steven J. Projan include Pfizer & British Society for Antimicrobial Chemotherapy.
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Journal ArticleDOI
Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule.
Richard P. Novick,H. F. Ross,Steven J. Projan,John Kornblum,Barry N. Kreiswirth,Soraya L. Moghazeh +5 more
TL;DR: It is shown that the cloned RNAIII determinant restores both positive and negative regulatory functions of agr to an agr‐null strain and that the RNA itself, rather than any protein, is the effector molecule.
Journal ArticleDOI
Tackling antibiotic resistance
Karen Bush,Patrice Courvalin,Gautam Dantas,Julian Davies,Barry I. Eisenstein,Pentti Huovinen,George A. Jacoby,Roy Kishony,Barry N. Kreiswirth,Elizabeth Kutter,Stephen A. Lerner,Stuart B. Levy,Kim Lewis,Olga Lomovskaya,Jeffrey H Miller,Shahriar Mobashery,Laura J. V. Piddock,Steven J. Projan,Christopher M. Thomas,Alexander Tomasz,Paul M. Tulkens,Timothy R. Walsh,James D. Watson,Jan A. Witkowski,Wolfgang Witte,Gerry Wright,Pamela J. Yeh,Helen I. Zgurskaya +27 more
TL;DR: To explore how the problem of antibiotic resistance might best be addressed, a group of 30 scientists from academia and industry gathered at the Banbury Conference Centre in Cold Spring Harbor, New York, USA, from 16 to 18 May 2011.
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Transcription Profiling-Based Identification of Staphylococcus aureus Genes Regulated by the agr and/or sarA Loci
Paul M. Dunman,Ellen Murphy,S. Haney,D. Palacios,G. Tucker-Kellogg,Shang Wei Wu,E. Brown,R. J. Zagursky,D. Shlaes,Steven J. Projan +9 more
TL;DR: Genes that are involved in several biological processes but which are difficult to reconcile as playing a direct role in the organism's pathogenesis also appeared to be regulated by each effector, suggesting that products of both the agr and the sarA locus are more-global transcription regulators than previously realized.
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Global Gene Expression in Staphylococcus aureus Biofilms
Karen E. Beenken,Paul M. Dunman,Fionnuala McAleese,D. Macapagal,Ellen Murphy,Steven J. Projan,Jon S. Blevins,Mark S. Smeltzer +7 more
TL;DR: This report uses a murine model of catheter-based biofilm formation to demonstrate that a UAMS-1 sarA mutant also has a reduced capacity to form a biofilm in vivo and identifies 48 genes in which expression was induced at least twofold in biofilms over expression under both planktonic conditions.
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Why is big Pharma getting out of antibacterial drug discovery
TL;DR: Since the advent of the antibiotic era in the late 1940s the cost and complexities of drug discovery and development have shifted the investment equation away from the development of drugs targeting short course therapies for acute diseases and towards long-term treatment of chronic conditions.