M
Markus E. Diefenbacher
Researcher at University of Würzburg
Publications - 41
Citations - 1783
Markus E. Diefenbacher is an academic researcher from University of Würzburg. The author has contributed to research in topics: Cancer & Transcription factor. The author has an hindex of 18, co-authored 34 publications receiving 1395 citations. Previous affiliations of Markus E. Diefenbacher include Karlsruhe Institute of Technology & London Research Institute.
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Journal ArticleDOI
The GATA2 Transcriptional Network Is Requisite for RAS Oncogene-Driven Non-Small Cell Lung Cancer
Madhu S. Kumar,David C. Hancock,Miriam Molina-Arcas,Michael Steckel,P East,Markus E. Diefenbacher,Elena Armenteros-Monterroso,Francois Lassailly,Nik Matthews,Emma Nye,Gordon Stamp,Axel Behrens,Julian Downward,Julian Downward +13 more
TL;DR: It is shown that RAS-pathway mutant NSCLC cells depend on the transcription factor GATA2, and discovery of the nononcogene addiction of KRAS mutant lung cancers to Gata2 presents a network of druggable pathways for therapeutic exploitation.
Journal ArticleDOI
RAS and RHO Families of GTPases Directly Regulate Distinct Phosphoinositide 3-Kinase Isoforms
Ralph Fritsch,Inge de Krijger,Kornelia Fritsch,Roger George,Beth Reason,Madhu S. Kumar,Markus E. Diefenbacher,Gordon Stamp,Julian Downward,Julian Downward +9 more
TL;DR: It is shown that both RAS and RHO family GTPases directly regulate distinct ubiquitous PI3K isoforms and that RAC activates p110β downstream of GPCRs and in fibroblasts through Dock180/Elmo1-mediated RAC activation and subsequent interaction with p110 β.
Journal ArticleDOI
Requirement for Interaction of PI3-Kinase p110α with RAS in Lung Tumor Maintenance
Esther Castellano,Clare Sheridan,May Zaw Thin,Emma Nye,Bradley Spencer-Dene,Markus E. Diefenbacher,Christopher Moore,Madhu S. Kumar,Miguel M. Murillo,Miguel M. Murillo,Eva Grönroos,Francois Lassailly,Gordon Stamp,Julian Downward,Julian Downward +14 more
TL;DR: The need for RAS interaction with p110α in the maintenance of mutant Kras-driven lung tumors was explored using an inducible mouse model and a tumor cell-autonomous effect was improved significantly by combination with MEK inhibition.
Journal ArticleDOI
The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer.
Markus E. Diefenbacher,Nikita Popov,Sophia M. Blake,Christina Schülein-Völk,Emma Nye,Bradley Spencer-Dene,Laura A. Jaenicke,Martin Eilers,Axel Behrens +8 more
TL;DR: Usp28 deficiency promoted tumor cell differentiation accompanied by decreased proliferation, which suggests that USP28 acts similarly in intestinal homeostasis and colorectal cancer models, and inhibition of the enzymatic activity ofUSP28 may be a potential target for cancer therapy.
Journal ArticleDOI
F-box and WD Repeat Domain-Containing 7 Regulates Intestinal Cell Lineage Commitment and Is a Haploinsufficient Tumor Suppressor
TL;DR: FbW7 regulates intestinal biology and tumorigenesis by controlling the abundance of different substrates in a dose-dependent fashion, providing a molecular explanation for the heterozygous mutations of fbw7 observed in human colorectal carcinoma.