Showing papers by "Markus Meissner published in 2010"

Letter: Therapy of Calcinosis Cutis Using Erbium‐Doped Yttrium Aluminum Garnet Laser Treatment

Abstract: Calcinosis cutis is a rare disorder that is characterized by deposits of calcium phosphate precipitate in the skin. The treatment options for calcinosis cutis are limited. There are only a few case reports describing successful systemic treatment using probenecid, diltiazem, colchicine, alendronate, or aluminium hydroxide. Unfortunately, these agents have not been useful in the treatment of most patients. The last course of treatment is surgical excision of the subcutaneous nodules. Excision is time consuming because of the numerous nodules, and morbidity is a concern. The symptoms indicating that surgical treatment is required are painful nodules, cosmetic concerns, ulcerations, or functional impairment.

Human leucocyte antigen class I and class II antigen expression in malignant fibrous histiocytoma, fibrosarcoma and dermatofibrosarcoma protuberans is significantly downregulated

Abstract: Background Abnormalities in the expression of human leucocyte antigens (HLA) by tumour cells impair cellular immune responses promoting immune evasion and tumour survival. To date, studies analysing HLA class I and class II expression levels in malignant fibrous histiocytomas, fibrosarcomas and dermatofibrosarcoma protuberans are limited. Aims Therefore, we investigated the in vivo expression profile of HLA class I and class II antigens in 99 malignant fibrous histiocytomas, 20 fibrosarcomas and 34 dermatofibrosarcoma protuberans from different anatomical sites. Material and methods Immunohistochemistry using monoclonal antibodies to HLA class I and class II antigens was used to define the expression levels of these antigens on respective tumour samples. Results Frequent loss or downregulation of HLA class I and class II expression in malignant fibrous tumours was observed for the different types of tumours examined. Discussion The data presented suggest for the first time a high frequency of HLA class I and class II abnormalities in malignant fibrous histiocytomas, fibrosarcomas and dermatofibrosarcoma protuberans in vivo. Conclusion This information might be useful in the practical and clinical design of tumour vaccination strategies.

A solid erythematous tumour

Abstract: A 4-mm punch biopsy taken from the lesion (Fig. 2a–c) revealed a broad and deeply infiltrating tumour. The epidermis appeared almost unchanged, except for slight epidermal hyperplasia (Fig. 2a). Higher magnification revealed large tumour cells with pale granular eosinophilic cytoplasm, giant lysosomal granules, and small, uniform, hyperchromatic, central nuclei, grouped into nests and irregularly arranged sheets (Fig. 2b). Tumour cells were S100-positive (Fig. 2c).