Showing papers in "Dermatologic Surgery in 2010"
TL;DR: Although the overall rate of complications associated with fractional laser skin resurfacing is much lower than with traditional ablative techniques, recent reports suggest that serious complications can develop.
Abstract: BACKGROUNDFractional photothermolysis represents a new modality of laser skin resurfacing that was developed to provide a successful clinical response while minimizing postoperative recovery and limiting treatment complications.OBJECTIVESTo review all of the reported complications that develop as a
247 citations
TL;DR: QS‐Nd:YAG laser treatment for melasma in Asians produced only temporary improvement and had side effects.
Abstract: BACKGROUND Pigment lasers have been used in melasma with unsatisfactory results.
OBJECTIVE To determine the effectiveness and safety of 1,064-nm Q-switched neodymium-doped yttrium aluminum garnet (QS-Nd:YAG) laser treatment of melasma in Asians.
MATERIALS AND METHODS Split-face randomized study comparing combination QS-Nd:YAG laser and 2% hydroquinone with topical treatment in dermal or mixed-type melasma. Twenty-two patients were treated with 1,064-nm QS-Nd:YAG laser, 6-mm spot size, 3.0- to 3.8-J/cm2 fluence for five sessions at 1-week intervals. Pigmentation was objectively recorded using a colorimeter (lightness index score), and subjective assessments were evaluated using the modified Melasma Area and Severity Index (mMASI) score.
RESULTS After five laser treatments, statistically significant improvement of melasma from baseline was observed in colorimeter (p<.001) and mMASI score (p<.001) on the laser side. The laser side achieved an average 92.5% improvement in relative lightness index and 75.9% improvement in mMASI, compared with 19.7% and 24%, respectively, on the control side (p<.001). Mottled hypopigmentation developed in three patients. During follow-up, four of 22 patients developed rebound hyperpigmentation, and all patients had recurrence of melasma.
CONCLUSION QS-Nd:YAG laser treatment for melasma in Asians produced only temporary improvement and had side effects. Common complications were hypopigmentation, melasma recurrence, and rebound hyperpigmentation.
The authors have indicated no significant interest with commercial supporters.
197 citations
TL;DR: Rheological evaluation enables the clinician to objectively classify soft tissue fillers, to select specific filler products based on scientific principles, and to reliably predict how these products will perform—lifting, supporting, and sculpting—after they are appropriately injected.
Abstract: BACKGROUNDTwo types of soft tissue filler that are in common use are those formulated primarily with calcium hydroxylapatite (CaHA) and those with cross-linked hyaluronic acid (cross-linked HA).OBJECTIVETo provide physicians with a scientific rationale for determining which soft tissue fillers are m
174 citations
TL;DR: Investigation of the noninferiority of incobotulinumtoxinA to another botulinum toxin type A to anotherbotulinum toxins type A in the treatment of glabellar frown lines confirmed that it is equally as effective as onabotulinu toxinA in the Treatment ofglabellar frowned lines.
Abstract: BACKGROUNDUse of botulinum toxin for esthetic purposes has rapidly expanded over the last 20 years. IncobotulinumtoxinA, also known as NT 201, is a new botulinum toxin type A (150 kDa) that is free from complexing proteins.OBJECTIVESA prospective, multicenter, randomized, rater- and patient-blind, i
110 citations
TL;DR: Modern sclerosants that have been subjected to rigorous experimental and clinical trials will provide even more efficacious and safer patient treatments.
Abstract: BACKGROUND Sclerotherapy is popular for the treatment of lower extremity telangiectasias and varicose and reticular veins. Although a large number of sclerosants are commonly employed, there are few data that directly compare their advantages and drawbacks. OBJECTIVES To analyze and present the differences between sclerosants that make them more or less suitable agents in specific clinical applications. MATERIALS AND METHODS A systemic review of published medical literature that compares and contrasts different classes of sclerosants is presented. RESULTS There is no perfect sclerosant that is complication free and 100% effective. The ability to match the sclerosant to the clinical problem being approached makes the availability of more Food and Drug Administration-approved sclerosants appealing. CONCLUSION Modern sclerosants that have been subjected to rigorous experimental and clinical trials will provide even more efficacious and safer patient treatments.
100 citations
TL;DR: This represents the largest single‐center study of high‐risk SCC supporting the use of Mohs micrographic surgery and found a low recurrence rate and disease‐specific mortality.
Abstract: Background Mohs micrographic surgery (MMS) is effective in the treatment of invasive cutaneous squamous cell carcinoma (SCC). High-risk SCC has a more guarded prognosis. Objectives To report the outcome of patients with high-risk SCCs treated with MMS. Methods and materials Two hundred fifteen patients with 260 high-risk cutaneous SCCs were reviewed in a single-center retrospective study, considering rates of recurrence, metastasis, and death. Cases were analyzed according to sex, age, immunocompetency status, tumor depth, lesion site, perineural disease, death rate, cause of death, secondary SCC, and melanoma. Seventy-seven percent of patients were male; 23% were female. Average age was 70.6. Twenty percent of patients were immunosuppressed. Mean follow-up was 3.9 years. Results There were three local recurrences (1.2%). Twelve (4.6%) tumors involved named nerve trunks. In eight of these cases, adjuvant radiation therapy was employed. Six (2.3%) tumors metastasized, with one fatality from disease. Seventy-five percent of patients developed another cutaneous SCC, and 7.7% developed a subsequent malignant melanoma. Conclusions MMS is an effective treatment for high-risk cutaneous SCC. This represents the largest single-center study of high-risk SCC supporting the use of MMS. Adjuvant radiotherapy was reserved for large-nerve perineural disease. There was a low recurrence rate and disease-specific mortality. Prompt recognition of metastatic disease allowed for curative therapy. Patients with one high-risk SCC are likely to develop secondary primary SCC and melanoma.
97 citations
TL;DR: Cyclic PDT with 5‐aminolevulinic acid may reduce the incidence of SCC in SOTRs and additional studies with larger numbers of patients and optimized protocols are necessary to further explore the potential benefits of cyclic PDT in the prevention of skin cancer in this high‐risk patient population.
Abstract: BACKGROUND AND OBJECTIVESSquamous cell carcinomas (SCCs) produce significant morbidity in solid organ transplant recipients (SOTRs), particularly in patients who develop multiple tumors. Topical photodynamic therapy (PDT) has been shown to decrease the number of keratotic lesions in SOTRs, but the d
95 citations
TL;DR: CO2 laser excision and marsupialization appears to be an effective therapy for management of persisent or late‐stage HS and there was good patient comfort during and after treatment, lower costs than with inpatient modalities, good healing, and minimal risk of recurrence within the treated areas.
Abstract: RESULTS One hundred eighty-five areas were treated in 61 patients using the CO2 laser excision and marsupialization technique in 154 sessions. Local anesthesia was used for all but three sessions. Healing occurred primarily through secondary intention. In follow-up from 1 to 19 years, acceptable to excellent qualities of healing occurred. Recurrence within the treated area occurred in two of 185 sites treated. CONCLUSION CO2 laser excision and marsupialization appears to be an effective therapy for management of persisent or late-stage HS. There was good patient comfort during and after treatment, lower costs than with inpatient modalities, good healing, and minimal risk of recurrence within the treated areas. The authors have indicated no significant interest with commercial supporters.
91 citations
TL;DR: This study sought to determine an in vitro dose‐response relationship between ovine testicular hyaluronidase and three HA dermal fillers and found that the 24‐mg/mL HA smooth gel filler exhibited more resistance against in vitro enzymatic degradation to OTH than the 20‐ and 5.3% lidocaine gels.
Abstract: BACKGROUNDAlthough adverse events are uncommon with hyaluronic acid (HA) fillers, the use of hyaluronidase permits the reversal of treatment complications or overcorrection.OBJECTIVEThis study sought to determine an in vitro dose-response relationship between ovine testicular hyaluronidase (OTH) and
88 citations
TL;DR: Surgical treatment of HS is effective and well tolerated, and in selected cases, the own techniques of surgical wound closure accelerated healing and improved results.
Abstract: OBJECTIVE To describe our own surgical techniques of wound closure in pubic and armpit areas in the treatment of hidradenitis suppurativa (HS) and to analyze surgical procedures performed with regard to complications, tolerance, and factors influencing recurrence rate.
METHODS Between 1999 and 2009, 118 operations were performed on 57 patients with HS. Surgical procedures included local excision of involved tissue and different methods of wound closure, including those of our own design such as the “star-like” technique and “pubic flaps.” Treatment tolerance was evaluated 3 months after surgery, and efficacy was evaluated after 24 months.
RESULTS Forty-four (77.2%) patients showed good tolerance of the operation and during the postoperative period, whereas only one individual (1.8%) reported unsatisfactory tolerance. Of all patients, 51 (89.5%) expressed willingness to undergo additional surgery in the event of lesion recurrence. During the 2-year follow-up period, complete recovery was observed in 34 (59.7%) patients, partial recovery in 18 (31.6%), and no improvement in five (8.8%). Factors influencing recurrence rate were number of skin areas affected by HS lesions and disease duration.
CONCLUSION Surgical treatment of HS is effective and well tolerated. In selected cases, our own techniques of surgical wound closure accelerated healing and improved results.
The authors have indicated no significant interest with commercial supporters.
84 citations
TL;DR: A comprehensive guide is needed for clinicians using this technology to treat specific skin conditions in various skin types using nonablative fractional photothermolysis.
Abstract: BACKGROUNDNonablative fractional photothermolysis has revolutionized the way we treat a number of common skin conditions with laser technology.OBJECTIVEA comprehensive guide is needed for clinicians using this technology to treat specific skin conditions in various skin types.MATERIALS AND METHODSRe
TL;DR: Based on a range of end points, onabotulinumtoxinA and 24‐mg/mL cohesive HA gel treatments are effective and safe when either alone or in combination to rejuvenate the lower face.
Abstract: BACKGROUND Combination treatment with toxins and fillers is the standard regimen in facial rejuvenation. Systematic studies of botulinum toxin alone and in combination with hyaluronic acid (HA) have not, however, been conducted in the lower face. OBJECTIVE To evaluate safety and effectiveness and compare combination treatment with onabotulinumtoxinA and a 24-mg/mL smooth, cohesive HA gel filler with either treatment alone for rejuvenation of the perioral area and lower face in female subjects. METHODS Ninety female participants aged 35 to 55 were randomized to one of three groups: 24-mg/mL cohesive gel alone (n=30), onabotulinumtoxinA alone (n=30), or the combination (n=30). Effectiveness outcomes included perioral, lip fullness, and oral commissure assessments and scores on the Cosmetic Improvement and Global Aesthetic Improvement Scales. Adverse events were monitored throughout. RESULTS For all end points and most time points, subjects treated with onabotulinumtoxinA plus the 24-mg/mL cohesive gel had greater improvement from baseline than subjects treated with onabotulinumtoxinA or the 24-mg/mL cohesive gel filler alone. CONCLUSION Based on a range of end points, onabotulinumtoxinA and 24-mg/mL cohesive HA gel treatments are effective and safe when either alone or in combination to rejuvenate the lower face. Combination therapy is superior to either modality used alone.
TL;DR: The results of this study indicate that the barbed suture lift was unable to accomplish the goals of less morbidity, less downtime, and greater patient satisfaction as well as obtaining outcomes comparable with those of an established widely used criterion standard.
Abstract: BACKGROUND Barbed suture lifting is a minimally invasive procedure for rejuvenation of the aging face. Few studies have examined its efficacy and associated risks. OBJECTIVES To evaluate the morbidity associated with this procedure and its long-term effects. METHODS AND MATERIALS A retrospective review of 29 cosmetic patients who underwent thread lifting was conducted. A chart review provided information on patient demographics, surgical technique, and postoperative course. RESULTS Analysis demonstrated that adverse events occurred in 69% and early recurrence in 45% of the patients in the study group. The incidence remained high upon extraction of independent variables, including technique used, location of thread placement, and number of threads placed. CONCLUSIONS Indications for performing minimally invasive cosmetic surgery include obtaining outcomes comparable with those of an established widely used criterion standard. The goal for new procedures should be to deliver predictable long-term results while providing less morbidity, less downtime, and greater patient satisfaction. The results of this study indicate that the barbed suture lift was unable to accomplish these goals. This study also reflects the importance of a critical review of the ever-expanding options available to aesthetic surgeons.
TL;DR: Laser treatment after topical TC cream was found to be safer and more effective than the post‐treatment use of topical agents.
Abstract: BACKGROUND Topical triple combination (TC) treatment is considered the primary approach to melasma. Recently, collimated low-fluence 1,064-nm Q-switched neodymium-doped yttrium aluminum garnet (Nd:YAG) laser treatment has attracted attention as an alternative approach. OBJECTIVES To compare the clinical efficacy and adverse effects of low-fluence Q-switched Nd:YAG laser when performed before and after treatment with topical TC using a split-face crossover design. METHODS Thirteen patients with melasma received topical treatment with TC cream or 1,064-nm Q-switched Nd:YAG laser treatment on opposite sides of the face for 8 weeks, and then treatments were reversed for 8 weeks. Responses were evaluated using the Melasma Area and Severity Index scoring system, spectrophotometry measurements, and a subjective self-assessment method. RESULTS After 16 weeks, better results were seen in subjective assessments when laser treatment was used after 8 weeks of topical TC treatment than before usage of TC. There were no significant adverse effects with the laser treatments. CONCLUSIONS Laser treatment after topical TC cream was found to be safer and more effective than the post-treatment use of topical agents.
TL;DR: The results strongly suggest that laser hair removal after surgical interventions in pilonidal sinus disease decreases the risk of recurrence over the long term.
Abstract: BACKGROUNDThe surgical treatments for pilonidal sinus disease often result in recurrences, and the patients risk requiring multiple surgical interventions.OBJECTIVETo evaluate the role of alexandrite laser hair removal after surgery in pilonidal sinus disease.METHODSSixty patients who underwent surg
TL;DR: Monitoring patients at risk for melanoma using TB photography was associated with lower biopsy rates and lower nevus‐to‐melanoma ratios than using DELM and facilitated detection of new and changing lesions.
Abstract: BACKGROUND Our previous experience monitoring nevi in high-risk patients using serial digital epiluminescence microscopy (DELM) photography achieved low biopsy rates but was limited by melanomas presenting as new lesions or arising from nevi that had not been photographed. OBJECTIVE To determine whether biopsy rates, efficiency of melanoma detection, and melanoma origin (de novo vs nevus derived) differed in a similar patient population monitored using total body (TB) photography. METHODS One thousand seventy-six patients (including 187 from a prior cohort) underwent TB photography and were monitored using photographs obtained at the initial visit. Risk factors and median monitoring periods for these patients were comparable with those of patients previously monitored using DELM photography. RESULTS Two hundred seventy-five biopsies were performed in 467 patients on follow-up visits. Of 12 melanomas detected on follow-up, five were invasive, five presented as changing lesions and two as new lesions, nine arose de novo, and the remainder were nevus derived. CONCLUSIONS In our experience with both approaches, monitoring patients at risk for melanoma using TB photography was associated with lower biopsy rates and lower nevus-to-melanoma ratios than using DELM and facilitated detection of new and changing lesions. In both cohorts, the majority of melanomas detected on follow-up arose de novo.
TL;DR: The findings showed that BoNTA injections result in improvements in quality of life (QOL) and self‐esteem, andBoNTA‐naïve participants demonstrate greater improvements in QOL and self-esteem than participants previously exposed to BoNta.
Abstract: OBJECTIVE To determine the effects that BoNTA injections for the treatment of facial wrinkles had on quality of life (QOL) and self-esteem. METHODS AND MATERIALS One hundred participants received treatment with BoNTA or placebo saline in this double-blind randomized placebo-controlled survey. All participants completed a health outcomes survey consisting of Quality of Life Enjoyment and Satisfaction QuestionnaireFShort Form and Heatherton and Polivy State Self-Esteem measurements before injection and 2 weeks and 3 months after injection. RESULTS Statistically significant improvements (po.05) in participants treated with BoNTA were observed in answers to QOL questions regarding physical health, mood, household activities, overall life satisfaction, body satisfaction, self-consciousness, intellect, self-worth, appearance, comprehension, weight satisfaction, attractiveness, and sense of well-being. Increases in overall self-esteem and appearance-, social-, and performance-related self-esteem were observed in participants treated with BoNTA. CONCLUSION Our findings showed that BoNTA injections result in improvements in QOL and selfesteem. In addition, BoNTA-nao¨ve participants demonstrate greater improvements in QOL and self-esteem than participants previously exposed to BoNTA. Moreover, BoNTA-familiar participants demonstrated sustained improvement in QOL and self-esteem relative to BoNTA-nao¨ve participants, even when injected with placebo. The authors have indicated no significant interest with commercial supporters.
TL;DR: By influencing the eyelash hair cycle and follicles, bimatoprost ophthalmic solution 0.03% is a safe and effective means of enhancing eyelash growth.
Abstract: BACKGROUNDMany women desire prominent eyelashes. In December 2008, bimatoprost ophthalmic solution 0.03% was approved for the treatment of hypotrichosis of the eyelashes in the United States.OBJECTIVETo review eyelash physiology and the proposed mechanisms by which the topical pros-tamide product bi
TL;DR: The potential application of an antiangiogenetic laser for the treatment of melasma specially accompanied by pronounced telangiectasia in Asian skin is a possible treatment option.
Abstract: BACKGROUND Melasma is a common pigmentary disorder in Asians. Although the pathogenesis of melasma is not yet fully understood, there are several hypotheses supporting angiogenetic factors related to some types of melasma.
OBJECTIVE To test the efficacy of copper bromide laser in the treatment of Korean women with melasma.
MATERIALS AND METHODS Clinical parameters included physician and patient assessment and Melasma Area and Severity Index score. The intensity of pigmentation and erythema was measured using a chromometer. To evaluate histopathologic changes, punch biopsies from melasma were obtained from four patients. Immunohistochemical staining for Melan-A, endothelin 1, CD34, and vascular endothelial growth factor (VEGF) antigen of the melasma lesions was observed.
RESULTS Mean MASI score decreased dramatically after treatment. Patients exhibited telangiectatic erythema within the melasma lesion. The values of L* reflecting intensity of pigmentation increased, and the values of a* as the measurement of redness decreased after the treatments. Expression of Melan-A, CD34, endothelin-1, and VEGF decreased after treatment.
CONCLUSION The potential application of an antiangiogenetic laser for the treatment of melasma specially accompanied by pronounced telangiectasia in Asian skin is a possible treatment option.
The authors have indicated no significant interest with commercial supporters.
TL;DR: It is demonstrated that the use of CO2 FS can have a positive therapeutic effect on late‐stage striae distensae.
Abstract: BACKGROUNDLate-stage striae distensae is a type of scar characterized by a loss of collagen and elastic fibers in the dermis. Ablative 10,600-nm carbon dioxide fractional laser systems (CO2 FS) have been used successfully for the treatment of various types of scars.OBJECTIVETo investigate the therap
TL;DR: Nodule formation is low, with most patients having good to excellent correction, and PLLA is a safe, biodegradable volumizer used to reverse the signs of aging by gradually correcting volume loss.
Abstract: BACKGROUND Poly-l-lactic acid (PLLA) is an effective treatment for patients seeking to correct volume loss due to aging. Although the Food and Drug Administration has approved PLLA for use in people with the human immunodeficiency virus (HIV), it is well-suited for patients seeking cosmetic treatment.
OBJECTIVE To evaluate the efficacy and incidence of adverse events of HIV-negative patients treated with PLLA for volume restoration.
MATERIALS AND METHODS This is a retrospective, single-center study of 130 HIV-negative patients treated with PLLA from 2003 to 2008. Patient satisfaction and incidence of adverse reactions were evaluated.
RESULTS The most common reaction to PLLA treatment was the formation of nodules (8.5%). Almost all of the nodules were palpable; only one was visible. Treatment areas with the highest incidence of post-treatment nodules were the hands (12.5%) and cheeks (7.2%). Overall, patients were satisfied, with 55% having good to excellent correction; 75% of patients with five or more treatments rated their correction as good to excellent. Sixty-eight percent of all patients would repeat the procedure again.
CONCLUSION PLLA is a safe, biodegradable volumizer used to reverse the signs of aging by gradually correcting volume loss. Patients should be aware of possible adverse reactions during the course of treatment. Nodule formation is low, with most patients having good to excellent correction.
Drs. Butterwick and Goldman are consultants for Sanofi-Aventis.
TL;DR: In this article, the authors explored the clinical application and use of high-frequency, high-resolution ultrasound in Mohs micrographic surgery and evaluated the ability of ultrasound to assess the skin.
Abstract: BACKGROUNDAlthough ultrasound imaging is employed ubiquitously today, its use to examine and assess the skin is a relatively new technology. We explored the clinical application and use of high-frequency, high-resolution ultrasound in Mohs micrographic surgery.OBJECTIVETo evaluate the ability of ult
TL;DR: The use of ultrasound may provide information to broaden the knowledge of facial fillers and may improve the performance and safety of filler treatments.
Abstract: BACKGROUNDInformation on fillers and their behavior over time in the different layers of tissue is limited. Ultrasound may be used to visualize these fillers and their surrounding tissue to broaden knowledge.OBJECTIVETo evaluate the use of ultrasound as a diagnostic and research tool to obtain infor
TL;DR: There is growing interest in a wide range of nonablative interventions that, predictably, are claimed to rejuvenate skin and subcutaneous tissue “safely and effectively” and to treat aesthetic aspect of aging.
Abstract: There is growing interest in a wide range of nonablative interventions that, predictably, are claimed to rejuvenate skin and subcutaneous tissue “safely and effectively.” Although for many years surgery in its many forms has been the criterion standard treatment in aesthetic aspect of aging, nonsurg
TL;DR: Fractional photothermolysis is effective for the treatment of acne scars, but practition‐ers should be aware of the higher incidence of pain and postinflammatory hyperpigmentation in individuals with skin types IV to VI.
Abstract: BACKGROUND Ablative resurfacing lasers are effective for treatment of acne scars, but they have a high risk of complications. Fractional lasers have less severe side effects but more moderate efficacy than ablative devices. Studies were performed in individuals with Fitzpatrick skin type I to VI.
OBJECTIVE To determine the efficacy and safety of an erbium 1,550-nm fractional laser in the treatment of facial acne scars in Fitzpatrick skin types IV to VI.
METHODS We conducted a prospective, single-blind, randomized trial in patients with acne scars (n=15), skin type IV to VI, with a 1,550-nm erbium fractionated laser. Patients were divided into two groups; one was treated with 10 mJ and the other with 40 mJ. Five monthly laser sessions were performed. A patient questionnaire was distributed.
RESULTS There was a significant improvement in the acne scarring and overall appearance (p<.001). No significant difference was found between 10 and 40 mJ. Patients were highly satisfied with their results. Significant postinflammatory hyperpigmentation was seen; pain was significantly higher in darker skin.
CONCLUSIONS Fractional photothermolysis is effective for the treatment of acne scars, but practition-ers should be aware of the higher incidence of pain and postinflammatory hyperpigmentation in individuals with skin types IV to VI.
The study was funded by Reliant Technologies, Inc., which participated in the study design. Galderma (Ft. Worth, TX) provided Tri-luma cream and GlaxoSmithKline (Research Triangle Park, NC) provided valacyclovir (Valtrex).
TL;DR: Observations are reported that provide a possible explanation for the in vivo preferentialFat tissue, being deficient in cell‐associated proteins and interstitial albumin, may be unable to sufficiently neutralize the detergent activity of DC, possibly making fat uniquely sensitive to DC.
Abstract: BACKGROUND Recent studies suggest that the principal active ingredient in phosphatidylcholine-containing injectable fat-reduction formulations is actually deoxycholate (DC). This bile acid acts as a detergent to rapidly disrupt cell membranes. Thus, it is not obvious why DC would preferentially target fat. OBJECTIVE To investigate possible mechanisms for the selectivity of DC for fat tissue using in vivo and in vitro models. METHODS AND MATERIALS Histology, drug distribution studies, and cell viability assays were used to examine possible mechanisms contributing to DC selectivity. RESULTS In vitro, DC caused the lysis of all cell types tested within the tested concentration range. DC injected into fat tissue caused adipocyte death, whereas other cell types appeared less affected. Physiological concentrations of albumin or protein-rich tissues decrease the ability of DC to lyse cells. Furthermore, DC relocated to the gastrointestinal tract in animals within hours of injection. This suggests that similar mechanisms may be present in humans. CONCLUSION We report observations that provide a possible explanation for the in vivo preferential fat targeting by DC. Fat tissue, being deficient in cell-associated proteins and interstitial albumin, may be unable to sufficiently neutralize the detergent activity of DC, possibly making fat uniquely sensitive to DC.
TL;DR: The procedure provides advantages in skin grafting for recalcitrant ulcers because PG functions as a delivery system of powerful mitogenic and chemostatic factors and FG as a hemostatic tissue sealant that avoids the use of staples or sutures.
Abstract: BACKGROUNDThere is no ideal procedure for the treatment of chronic skin ulcers. The use of platelet gel (PG) in this indication is raising interest.OBJECTIVETo evaluate the safety and efficacy of a new procedure combining allogeneic single-donor PG and fibrin glue (FG) to enhance skin graft take for
TL;DR: Par paradoxical hypertrichosis is a rare side effect of laser hair removal; the pathogenesis of this event remains widely unknown and the authors recommend further large‐scale studies to investigate this effect.
Abstract: BACKGROUNDLaser hair removal is a safe and effective procedure for the treatment of unwanted body hair but is not exempt from side effects. A rare but significant adverse effect with this treatment modality is paradoxical hypertrichosis.OBJECTIVETo evaluate the potential etiologies, risk factors, re
TL;DR: RT001 was well tolerated and demonstrated an improvement in LCLs, and this study was sponsored by Revance Therapeutics, Inc, Newark, CA.
Abstract: BACKGROUNDBotulinum toxin type A (BoNTA) is commonly injected to treat facial wrinkles. Complications include pain, erythema, bruising, and potential infection. RT001 Botulinum Toxin Type A Topical Gel (RT001) is under development for the treatment of lateral canthal lines (LCLs).OBJECTIVETo assess