M
Markus Schirle
Researcher at Novartis
Publications - 91
Citations - 16037
Markus Schirle is an academic researcher from Novartis. The author has contributed to research in topics: Ubiquitin ligase & Protein degradation. The author has an hindex of 38, co-authored 80 publications receiving 14202 citations. Previous affiliations of Markus Schirle include University of Tübingen & University of California, Berkeley.
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Drug-induced eRF1 degradation promotes readthrough and reveals a new branch of ribosome quality control
L.-A. Gurzeler,Marion Link,Yvonne Ibig,Isabel Schmidt,Olaf Galuba,Julian Schoenbett,Christelle Gasser-Didierlaurant,Christian N. Parker,Xiaohong Mao,Francis Bitsch,Markus Schirle,Philippe Couttet,Frederic Sigoillot,Jana Ziegelmüller,Anne-Christine Uldry,Niko Schmiedeberg,Oliver Mühlemann,Jürgen Reinhardt +17 more
TL;DR: In this paper , two readthrough promoters, NVS1.1 and NVS2.1, are proposed to suppress premature termination codons by triggering rapid proteasomal degradation of the translation termination factor eRF1.