Markus Schirle

TL;DR: A comparison between the TAP translocation efficiency of wild-type and mutant peptide demonstrated that the mutation at the C-terminus leads to a reduced transportation rate and the amino acid substitution changes the in vitro proteasomal cleavage pattern, resulting in a reduced liberation of the correct peptide from a polypeptide precursor.

TL;DR: This work provides detailed insight into a distinct binding pocket within the v-ATPase complex responsible for proton translocation in HTP-013, a member of the lignan natural product family which exhibited significant cytotoxicity across various cancer cell lines.

TL;DR: In this article , a transposable chemical handle was proposed to convert protein-targeting ligands into molecular degraders of their corresponding targets, which showed improved interactions with RING family E3 ubiquitin ligase RNF126.

TL;DR: It is shown for the first time that Chivosazole F exerts its effect by directly interacting with actin and the cellular impact is demonstrated in an unbiased, genome-wide context in yeast and in mammalian cells.