M
Markus Stein
Researcher at University of British Columbia
Publications - 11
Citations - 1810
Markus Stein is an academic researcher from University of British Columbia. The author has contributed to research in topics: Intimin & Actin nucleation. The author has an hindex of 6, co-authored 10 publications receiving 1773 citations.
Papers
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Journal ArticleDOI
Enteropathogenic E. coli (EPEC) Transfers Its Receptor for Intimate Adherence into Mammalian Cells
Brendan Kenny,Rebekah DeVinney,Markus Stein,Dieter J. Reinscheid,Elizabeth A. Frey,B. Brett Finlay +5 more
TL;DR: It is demonstrated that Hp90 is actually a bacterial protein (Tir), to which this bacterial pathogen inserts its own receptor into mammalian cell surfaces, to which it then adheres to trigger additional host signaling events and actin nucleation.
Journal ArticleDOI
Enterohemorrhagic Escherichia coli O157:H7 Produces Tir, Which Is Translocated to the Host Cell Membrane but Is Not Tyrosine Phosphorylated
Rebekah DeVinney,Markus Stein,Dieter J. Reinscheid,Akio Abe,Sharon Ruschkowski,B. Brett Finlay +5 more
TL;DR: It is demonstrated that EHEC produces a functional Tir that is inserted into host cell membranes, where it serves as an intimin receptor, however, unlike in EPEC, in EH EC Tir is not tyrosine phosphorylated yet plays a key role in both bacterial adherence to epithelial cells and pedestal formation.
Journal ArticleDOI
Enteropathogenic Escherichia coli protein secretion is induced in response to conditions similar to those in the gastrointestinal tract.
TL;DR: It is shown that the secretion of EspB is subject to environmental regulation, and maximal secretion occurs under conditions reminiscent of those in the gastrointestinal tract, and that secretion is not dependent on CO2.
Journal ArticleDOI
Characterization of two virulence proteins secreted by rabbit enteropathogenic Escherichia coli, EspA and EspB, whose maximal expression is sensitive to host body temperature.
TL;DR: Investigation of the function of EspA and EspB in RDEC-1 revealed that the corresponding RD EC-1 gene products are essential for triggering of host signal transduction pathways and invasion into HeLa cells, although the EPEC proteins mediated higher levels of invasion.
Patent
Pathogenic Escherichia coli associated protein
TL;DR: In this paper, the EspA polypeptide which is secreted by pathogenic E. coli, such as the enteropathogenic (EPEC) and enterohemorrhagic (EHEC) E coli, is described.