M
Marleen M. Wekell
Researcher at Food and Drug Administration
Publications - 52
Citations - 1972
Marleen M. Wekell is an academic researcher from Food and Drug Administration. The author has contributed to research in topics: Bioassay & Oyster. The author has an hindex of 24, co-authored 52 publications receiving 1898 citations.
Papers
More filters
Journal ArticleDOI
Tetrazolium-Based Cell Bioassay for Neurotoxins Active on Voltage-Sensitive Sodium Channels: Semiautomated Assay for Saxitoxins, Brevetoxins, and Ciguatoxins
TL;DR: An assay for the detection of sodium channel-specific marine toxins based upon mitochondrial dehydrogenase activity in the presence of veratridine and ouabain is developed and has the potential to serve as an alternate and complementary method to the standard mouse bioassay.
Journal ArticleDOI
Detection of sodium channel toxins: directed cytotoxicity assays of purified ciguatoxins, brevetoxins, saxitoxins, and seafood extracts.
R.L. Manger,Linda S. Leja,Sookwang Lee,James M. Hungerford,Y. Hokama,Robert Wayne Dickey,Hudson R. Granade,Richard J. Lewis,Takeshi Yasumoto,Marleen M. Wekell +9 more
TL;DR: Neuroblastoma cells in culture were used to detect sodium channel-specific marine toxins based on an end-point determination of mitochondrial dehydrogenase activity, and the results obtained from cell bioassay of ciguatoxic finfish extracts correlates with those obtained from mouse bioassays.
Journal ArticleDOI
Virulent strains of Vibrio vulnificus isolated from estuaries of the United States West Coast.
TL;DR: Vibrio vulnificus was isolated from United States West Coast estuaries at a low frequency from 529 samples of water, shellfish, and sediment and species-specific antiflagellar serum and a gene probe for cytotoxin-hemolysin production were useful for screening these environmental isolates.
Journal ArticleDOI
Listeria species in a California coast estuarine environment.
TL;DR: A given species or L. monocytogenes serogroup appeared to predominate in fresh water when domesticated animals were nearby, whereas greater variety with no species predominance was observed in areas with no direct animal influence.
Journal ArticleDOI
Recovery of Aeromonas hydrophila from oysters implicated in an outbreak of foodborne illness.
TL;DR: Twenty-three of 28 strains identified by the MICRO-IS and API-20E systems were positive for at least one of the tests for virulence which included the suckling mouse test, the adrenal Y-1 mouse cell test, and hemolysin assays, which suggest that in cases of foodborne illness involving oysters, A. hydrophila should be included in the screening tests.