Marta Caro

TL;DR: ASCs induce a distinct regulatory activation state of macrophages which possess potent immunomodulatory ability and therapeutic potential in inflammatory bowel diseases and sepsis.

TL;DR: Insight is provided into the beneficial effects observed when these cells are used in therapeutic approaches in vivo and evidence that macrophages re‐educated by CM improve tissue regeneration/repair in wound‐healing models is provided.

TL;DR: Findings might contribute to explain the differences in the onset and progression of this highly debilitating disease, which could be of value in the development of rational approaches towards effective control of immune responses that are associated with PD.

TL;DR: Neuropeptides exerted their trypanolytic activity through an unusual mechanism that involves peptide uptake by the parasite, disruption of lysosome integrity and cytosolic accumulation of glycolytic enzymes, which promotes an energetic metabolism failure that initiates an autophagic-like cell death.

TL;DR: The vasoactive intestinal peptide is used as an example of an immunomodulatory neuropeptide to summarize the most relevant data found for other neuropepeptides with similar characteristics, including adrenomedullin, urocortin, cortistatin and ghrelin.