F
Francisco O'Valle
Researcher at University of Granada
Publications - 20
Citations - 2122
Francisco O'Valle is an academic researcher from University of Granada. The author has contributed to research in topics: NADPH oxidase & Endothelium. The author has an hindex of 17, co-authored 20 publications receiving 1964 citations. Previous affiliations of Francisco O'Valle include Complutense University of Madrid.
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Journal ArticleDOI
Human adipose-derived mesenchymal stem cells reduce inflammatory and T-cell responses and induce regulatory T cells in vitro in rheumatoid arthritis
Elena Gonzalez-Rey,Manuel A. González,Nieves Varela,Francisco O'Valle,Pedro Hernández-Cortés,Laura Rico,Dirk Büscher,Mario Delgado +7 more
TL;DR: In this paper, the authors investigated the effects of mesenchymal stem cells on collagen-reactive RA human T-cell proliferation and cytokine production, as well as on the production of inflammatory mediators by monocytes and fibroblast-like synoviocytes.
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Adipose-derived mesenchymal stromal cells induce immunomodulatory macrophages which protect from experimental colitis and sepsis
Per Anderson,Luciana Souza-Moreira,Maria Morell,Marta Caro,Francisco O'Valle,Elena Gonzalez-Rey,Mario Delgado +6 more
TL;DR: ASCs induce a distinct regulatory activation state of macrophages which possess potent immunomodulatory ability and therapeutic potential in inflammatory bowel diseases and sepsis.
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Protective effects of the flavonoid quercetin in chronic nitric oxide deficient rats
Juan Duarte,Rosario Jiménez,Francisco O'Valle,Milagros Galisteo,Raquel Pérez-Palencia,Félix Vargas,Francisco Perez-Vizcaino,Antonio Zarzuelo,Juan Tamargo +8 more
TL;DR: Quercetin markedly inhibited the development of l-NAME-induced hypertension in rats and confirms and extends the previous evidence about the antihypertensive effects and end-organ protection of the flavonoid quercet in animal models of hypertension.
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Quercetin inhibits vascular superoxide production induced by endothelin-1: Role of NADPH oxidase, uncoupled eNOS and PKC.
Miguel Romero,Rosario Jiménez,Manuel Castro Sánchez,Rocío López-Sepúlveda,María José Zarzuelo,Francisco O'Valle,Antonio Zarzuelo,Francisco Perez-Vizcaino,Juan Duarte +8 more
TL;DR: Results indicate that ET-1-induced NADPH oxidase up-regulation and eNOS uncoupling via PKC leading to endothelial dysfunction and these effects were prevented by quercetin and isorhamnetin.
Journal ArticleDOI
Automatic quantification of liver fibrosis: design and validation of a new image analysis method: comparison with semi-quantitative indexes of fibrosis.
Marco Masseroli,T. Caballero,Francisco O'Valle,Raimundo G. del Moral,Alejandro Pérez-Milena,Raimundo G. M. Del Moral +5 more
TL;DR: FibroQuant is a sensitive, precise, objective and reproducible method of fibrosis quantification, which complements semi-quantitative histologic evaluation systems and could be of special value in clinical trials and for improving the prognosis and follow-up among patients with fibrosis-inducing hepatic diseases.