M
Martin A. Claydon
Researcher at Manchester Metropolitan University
Publications - 5
Citations - 1116
Martin A. Claydon is an academic researcher from Manchester Metropolitan University. The author has contributed to research in topics: Mass spectrometry & Top-down proteomics. The author has an hindex of 5, co-authored 5 publications receiving 1072 citations.
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The rapid identification of intact microorganisms using mass spectrometry
TL;DR: The application of MALDI-TOF-MS is reported for the identification of intact Gram-negative and Gram-positive microorganisms taken directly from culture, providing a unique mass spectral fingerprint of the microorganism, produced from desorbed components of the cell wall.
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Rapid discrimination between methicillin-sensitive and methicillin-resistant Staphylococcus aureus by intact cell mass spectrometry
TL;DR: ICMS spectra for 20 staphylococcal isolates showed characteristic peaks, some of which were conserved at species level, some at strain level and some were characteristic of the methicillin susceptibility status of the strain.
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Rapid typing of bacteria using matrix-assisted laser desorption ionisation time-of-flight mass spectrometry and pattern recognition software
TL;DR: The ability to acquire ICM-MS fingerprints of bacteria and to search a database of these fingerprints within minutes is acquired, so that the rapid identification of bacteria to the strain level can be realised.
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Effects of ion mode and matrix additives in the identification of bacteria by intact cell mass spectrometry.
TL;DR: Protocols for the identification of bacterial cells by intact cell matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (ICM-TOFMS) are presented and the use of formic acid and the crown ether 1, 4, 7, 10, 13, 16-hexaoxacyclooctadecane (18-crown-6) is described.
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Exploring the limits of bacterial identification by intact cell-mass spectrometry.
TL;DR: The limits of intact cell-mass spectrometry (ICM-MS) were tested with regard to the minimum number of bacterial cells detectable and its power to discriminate mixed-bacterial cultures and UV absorbing matrices were found to be highly specific to bacterial gram type.