Martin Kenny

TL;DR: Goedhart et al. as discussed by the authors presented a web interface for the creation of SuperPlots, which can be used to display cell-level variability within replicates as well as the experimental reproducibility between replicates in one single plot.

TL;DR: In a model of melanoma, treatment with low molecular weight heparin (LMWH) negatively regulated VWF secretion and attenuated tumor metastasis, and elevated plasma VWF levels constitute an independent biomarker for VTE risk.

TL;DR: In this paper, the authors used three mouse lines, each with one point mutation in the Myh9 gene at positions 702, 1424, or 1841, to investigate mechanisms underlying the increased bleeding risk.

TL;DR: Deep vein thrombosis describes the clogging of veins in extremities, leading to pain, swelling, and potentially lifethreatening pulmonary embolism, where long-term immobilization of hospitalized patients is thought to provoke DVT through reducing blood flow in the legs.

TL;DR: These are novel mechanobiology mechanisms by which platelets spearhead the fibrillogenesis of the first de novo ECM, including its 2D versus 3D network architectures depending on their ECM environment, and thereby pave the way for cell infiltration.