Jamie M. O’Sullivan

TL;DR: It is suggested that the diffuse bilateral pulmonary inflammation observed in COVID19 is associated with a novel pulmonary‐specific vasculopathy termed pulmonary intravascular coagulopathy (PIC) as distinct to DIC, which may contribute to the unexplained differences that are beginning to emerge highlighting racial susceptibility toCOVID19 mortality.

TL;DR: In this paper, the authors assess whether endothelial cell activation may be sustained in convalescent COVID-19 patients and contribute to long COVID pathogenesis, and demonstrate that sustained endotheliopathy was more frequent in older, comorbid patients and those requiring hospitalization.

TL;DR: In this paper, the authors hypothesized that pulmonary microvascular immuno-thrombosis may be important in this context, and found that increased D-dimer levels (>500 ng/ml) were observed in 25.3% patients up to 4 months post SARS-CoV-2 infection.

TL;DR: The authors showed that endothelial cells play a key role in orchestrating the unusual pulmonary intravascular coagulopathy associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

TL;DR: The novel data suggest that low VWF levels can be associated with significant bleeding and are predominantly due to reductions in VWF synthesis and/or constitutive secretion.