M
Martin Purtscher
Researcher at University of Agriculture, Faisalabad
Publications - 18
Citations - 2556
Martin Purtscher is an academic researcher from University of Agriculture, Faisalabad. The author has contributed to research in topics: Monoclonal antibody & Antibody. The author has an hindex of 14, co-authored 18 publications receiving 2501 citations. Previous affiliations of Martin Purtscher include University of Agricultural Sciences, Dharwad.
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Generation of human monoclonal antibodies against HIV-1 proteins; electrofusion and Epstein-Barr virus transformation for peripheral blood lymphocyte immortalization.
Andrea Buchacher,Renate Predl,K. Strutzenberger,Willibald Steinfellner,Alexandra Trkola,Martin Purtscher,Gerhard Gruber,Christopher Tauer,Franz Steindl,Alois Jungbauer,Hermann Katinger +10 more
TL;DR: Electrofusion turned out to be a more efficient immortalization method than EBV transformation, due to a high and constant immortalization rate, and the yield of stable specific hybridomas was increased twofold.
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A potent cross-clade neutralizing human monoclonal antibody against a novel epitope on gp41 of human immunodeficiency virus type 1.
Gabriela Stiegler,Renate Kunert,Martin Purtscher,Susanne Wolbank,Regina Voglauer,Franz Steindl,Hermann Katinger +6 more
TL;DR: 4E10 neutralizes potently not only tissue culture-adapted strains but also primary isolates of different clades, including A, B, C, D, and E, confirming that the region recognized by 2F5 and 4E10 is essential for viral infectivity and may be important for vaccine design.
Journal ArticleDOI
A Broadly Neutralizing Human Monoclonal Antibody against gp41 of Human Immunodeficiency Virus Type 1
Martin Purtscher,Alexandra Trkola,Gerhard Gruber,Andrea Buchacher,Renate Predl,Franz Steindl,Christa Tauer,Rudolf Berger,Noel Barrett,Alois Jungbauer,Hermann Katinger +10 more
TL;DR: A hybridoma clone, designated 2F5, secreting a neutralizing human monoclonal antibody specific for gp41 of human immunodeficiency virus type 1 (HIV-1) showed broad-spectrum neutralizing capacity against HIV-1 laboratory isolates IIIB, MN, RF, and SF2.
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Cross-neutralizing activity against divergent human immunodeficiency virus type 1 isolates induced by the gp41 sequence ELDKWAS
Thomas Muster,R Guinea,Alexandra Trkola,Martin Purtscher,Annelies Klima,Franz Steindl,Peter Palese,Hermann Katinger +7 more
TL;DR: The results suggest that this conserved B-cell epitope is a promising candidate for inclusion in a vaccine against AIDS and show that influenza virus can be used to effectively present the antigenic structure of this B- cell epitope.
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Restricted antigenic variability of the epitope recognized by the neutralizing gp41 antibody 2F5.
Martin Purtscher,Alexandra Trkola,Andreas Grassauer,Petra Schulz,Annelies Klima,Susanne Döpper,Gerhard Gruber,Andrea Buchacher,Thomas Muster,Hermann Katinger +9 more
TL;DR: In this article, variations of the conserved gp41 amino-acid sequence ELDKWA were investigated to investigate whether they affect its binding or neutralization by monoclonal antibody (MAb) 2F5.