M
Martin Ried
Researcher at MediGene
Publications - 23
Citations - 2326
Martin Ried is an academic researcher from MediGene. The author has contributed to research in topics: Virus & Adeno-associated virus. The author has an hindex of 11, co-authored 22 publications receiving 2226 citations. Previous affiliations of Martin Ried include Ludwig Maximilian University of Munich.
Papers
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Journal ArticleDOI
Real-time single-molecule imaging of the infection pathway of an adeno-associated virus.
Georg Seisenberger,Martin Ried,Thomas Endreß,Hildegard Büning,Michael Hallek,Christoph Bräuchle +5 more
TL;DR: A method, based on single-molecule imaging, that allows the real-time visualization of the infection pathway of single viruses in living cells, each labeled with only one fluorescent dye molecule shows a much faster infection than was generally observed so far.
Journal ArticleDOI
Genetic capsid modifications allow efficient re-targeting of adeno-associated virus type 2.
Anne Girod,Martin Ried,Christiane E. Wobus,Harald Lahm,Kristin Leike,Jürgen A. Kleinschmidt,Gilbert Deléage,Michael Hallek +7 more
TL;DR: The results demonstrate that the AAV2 capsid tolerates the insertion of a nonviral ligand sequence, which might open new perspectives for the design of targeted A AV2 vectors for human somatic gene therapy.
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The VP1 capsid protein of adeno-associated virus type 2 is carrying a phospholipase A2 domain required for virus infectivity.
Anne Girod,Christiane E. Wobus,Zoltán Zádori,Martin Ried,Kristin Leike,Peter Tijssen,Jürgen A. Kleinschmidt,Michael Hallek +7 more
TL;DR: Results suggest that pvPLA2 activity is required for a step following perinuclear accumulation of virions but prior to early gene expression, as measured by Rep immunofluorescence.
Journal ArticleDOI
In vitro selection of viral vectors with modified tropism: the adeno-associated virus display.
Luca Perabo,Hildegard Büning,David M. Kofler,Martin Ried,Anne Girod,Clemens M. Wendtner,Jörg Enssle,Michael Hallek +7 more
TL;DR: The results demonstrate for the first time that a combinatorial approach based on a eukaryotic virus library allows one to generate efficient, receptor-specific targeting vectors with desired tropism.
Journal ArticleDOI
Receptor targeting of adeno-associated virus vectors.
Hildegard Büning,Martin Ried,Luca Perabo,Franz M. Gerner,N A Huttner,Jörg Enssle,Michael Hallek +6 more
TL;DR: The studies summarized in this review show that it is possible to target AAV-2 to a specific cell, and the most promising approach is the genetic modification of the viral capsid.