M
Martina Wirth
Researcher at Francis Crick Institute
Publications - 14
Citations - 625
Martina Wirth is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: Autophagy & GABARAP. The author has an hindex of 7, co-authored 12 publications receiving 457 citations. Previous affiliations of Martina Wirth include London Research Institute & Leiden University Medical Center.
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Journal ArticleDOI
Autophagosome formation--the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage.
TL;DR: How the mammalian ULK1 and Beclin1 complexes are controlled by post-translational modifications and protein-protein interactions is discussed and data linking these complexes together is highlighted.
Journal ArticleDOI
Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins.
Martina Wirth,Wenxin Zhang,Minoo Razi,Lynet Nyoni,Dhira Joshi,Nicola O’Reilly,Terje Johansen,Sharon A. Tooze,Stephane Mouilleron +8 more
TL;DR: It is shown that in addition to the LIR motif also the region C-terminal of it is important for the binding specificity of both the centriolar satellite protein PCM1 and the ULK1 complex to GABARAP subfamily proteins.
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Centriolar Satellites Control GABARAP Ubiquitination and GABARAP-Mediated Autophagy
Justin Joachim,Minoo Razi,Delphine Judith,Martina Wirth,Emily Calamita,Vesela Encheva,Brian David Dynlacht,Ambrosius P. Snijders,Nicola O’Reilly,Harold B.J. Jefferies,Sharon A. Tooze +10 more
TL;DR: A mechanism for how centriolar satellites can specifically regulate an ATG8 ortholog, the centrosomal GABARAP reservoir, and centrosome-autophagosome crosstalk is suggested.
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ATG4B contains a C-terminal LIR motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8.
Mads Skytte Rasmussen,Stephane Mouilleron,Birendra Kumar Shrestha,Martina Wirth,Rebecca Lee,Kenneth Bowitz Larsen,Yakubu Abudu Princely,Nicola O’Reilly,Eva Sjøttem,Sharon A. Tooze,Trond Lamark,Terje Johansen +11 more
TL;DR: It is shown that ATG4B contains a C-terminal LC3-interacting region (LIR) motif important for efficient binding to and cleavage of LC3 and GABARAP proteins.
Journal ArticleDOI
Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs.
Åsa Birna Birgisdottir,Stephane Mouilleron,Zambarlal Bhujabal,Martina Wirth,Eva Sjøttem,Gry Evjen,Wenxin Zhang,Rebecca Lee,Nicola O’Reilly,Sharon A. Tooze,Trond Lamark,Terje Johansen +11 more
TL;DR: GABARAP-preferring LIR motifs in PIK3C3, BECN1 and ATG14 may, via coincidence detection, contribute to scaffolding of PtdIns3K-C1 on membranes for efficient autophagosome formation.