Martine Courtois

TL;DR: It is predicted that the translocation of pathway intermediates from the internal phloem parenchyma to the epidermis and, ultimately, to laticifers and idioblasts during MIA biosynthesis is likely to be required.

TL;DR: Two periwinkle cDNAs encoding enzymes of the non-mevalonate terpenoid pathway were characterized using reverse transcription-PCR strategy based on the design of degenerated oligonucleotides and the deduced amino acid sequence of crdxr is homologue to 1-deoxy-D-xylulose 5-phosphate reductoisomerases.

TL;DR: Since regulatory genes encoding transcription factors acting on several genes of the MEP and terpenoid pathways are beginning to be characterised, metabolic engineering of the iridoid pathway could be a promising approach to control the metabolite flux towards secologanin and MIA production through biotechnological applications in the future.

TL;DR: It is concluded that protein targets for both PFT and PGGT-I are required for the expression of ESMB genes and monoterpenoid biosynthesis in C. roseus, this represents a non previously described role for protein prenyltransferase in plants.

TL;DR: A new series of analogues of fosmidomycin, containing a Benzoxazolone, benzoxazolethione or oxazolopyridinone ring are synthesized, which show significant inhibition of ajmalicine accumulation in Catharanthus roseus cells.