Mary P. Carroll

TL;DR: In sensitized asthmatics, local endobronchial allergen instillation leads to an increased inflammatory cell infiltrate of the airway mucosa that involves upregulation of specific adhesion molecules expressed on the microvasculature.

TL;DR: The identification of multiple lymphocyte chemoattractants early after antigen challenge suggests a complex cellular, as well as chemeattractant cytokine, profile in initiating the CD4+ T cell-mediated inflammatory process that is specific for the atopic asthmatic phenotype.

TL;DR: Neutrophil infiltration is a nonspecific response to the procedure of bronchoscopy and lavage, in contrast to eosinophil recruitment, which is an allergen-specific phenomenon, and it suggests that IL-8 release may be involved in neutrophil recruitment.

TL;DR: The superior physical properties of UFH/L-leucine indicate this is the preferred formulation for development as an inhaled mucolytic for lung disease in patients with cystic fibrosis.