Showing papers in "Journal of Pharmaceutical Sciences in 2008"

TL;DR: The requirement for formulations with improved properties for effective and accurate delivery of the required therapeutic agents and general formulation approaches towards achieving optimum physical properties and controlled delivery characteristics for an active wound healing dosage form are considered.

TL;DR: This review focuses on the chemical structure of the polysorbates, factors influencing micelle formation and factors and excipients influencing stability and degradation of thepolyethylene and fatty acid ester linkages.

TL;DR: The current knowledge of enzymatic and nonenzymatic modifications of monoclonal antibodies including the common ones such as incomplete disulfide bond formation, glycosylation, N-terminal pyroglutamine cyclization, C- terminal lysine processing, deamidation, isomerization, and oxidation are reviewed.

TL;DR: Whereas most approaches to drug development seek to increase the activity of drugs directly, the creation of PEGylated drugs seeks to balance the pharmacodynamic (PD) and pharmacokinetic properties to produce novel therapies that will meet with both increased efficacy and greater compliance in the clinical setting.

TL;DR: The fabrication and chemical modifications of porous silicon for biomedical applications, and also the potential advantages of PSi in drug delivery are reviewed.

TL;DR: The potential of dendrimers to be applied in these detailed routes with particular reference to intravenous, oral, transdermal, and ocular delivery systems is demonstrated.

TL;DR: An increased understanding of the relative contributions of molecular mobility and processing conditions are vital to increased usage of the amorphous state in solid oral dosage forms.

TL;DR: The data showed that shaking and stirring resulted in different species of aggregates both qualitatively and quantitatively, where stirring was found more stressful than shaking on the IgG1 formulation.

TL;DR: An overview of principles and barriers relevant to intracellular drug and gene transport, accumulation and retention by means of nanovehicles (NV) and "elementary" phenomena related to different level of complexity of delivery to cancer are listed.

TL;DR: Though the measured enthalpy was similar for all three Fab fragments studied, the apparent melting temperatures were found to vary significantly, even for Fab fragments originating from the same human germline, which may be an indication of significant structural heterogeneity and/or of disruption of the Fab cooperative unfolding.

TL;DR: It is indicated that a charge effect may be a more important factor than the chaotropic nature of excipients in reducing solution viscosity by breaking network self-association of a MAb.

TL;DR: It is now possible to envisage adventurous applications for polyester microparticles beyond their inherent role as biodegradable, controlled drug delivery vehicles, which may include drug Delivery vehicles for the treatment of cerebral disease and tumor targeting, and co-delivery of drugs in a pulsatile and/or time-delayed fashion.

TL;DR: The rationale for selecting optimal strategies of liposomal drug formulations with respect to drug encapsulation, retention, and release, and how these strategies can be applied to maximize therapeutic benefit in vivo are described.

TL;DR: Using a diverse set of 18 commercially available drugs spanning a range of physicochemical properties, this methodology is shown to be a robust and accurate methodology, with a shorter preparation and dialysis time, capable of being automated as a high-throughput assay for the determination of PPB.

TL;DR: This review compares the different formulations of amphotericin B in terms of pharmacokinetics, toxicity and activity and discusses the possible drug targeting effect of some of these new formulations.

TL;DR: The present review surveys various themes related to the accomplishment of the correct timing of the events leading to optimal drug action in the joint space over a desired time period.

TL;DR: This review summarizes the peptide/protein chemical degradation reactions that have been reported in PLGA systems and their mechanisms and the reported methods for stabilizing peptides and proteins inPLGA devices.

TL;DR: Variation of the feed weight ratio of MePEG to caprolactone resulted in the synthesis of copolymers with predictable block lengths, and the aqueous solubilities of the model hydrophobic drugs, indomethacin, curcumin, plumbagin, paclitaxel, and etoposide were increased by encapsulation within the micelles.

TL;DR: The aim of present investigation was to screen different solvents for optimizing nanoparticle preparation in terms of particle size, entrapment efficiency, and finally, release behavior using a model drug estradiol to suggest that particle size has significant role in determining the fate of nanoparticles in vivo.

TL;DR: The article summarizes the level of research with respect to dermal and transdermal application of microemulsions and finds that drugs incorporated into microemulsion penetrate efficiently into the skin.

TL;DR: Investigation of the suspension formulation revealed that AMG 517 forms a co-crystal with sorbic acid, a preservative in OraPlus, which has better aqueous solubility initially as compared to AMg 517 free base but does revert back to a form of the free base hydrate during prolonged slurry in FaSIF (fasted simulated intestinal fluid).

TL;DR: In this article, the authors developed a model to predict drug transport from the intestinal lumen into the bloodstream using cell culture models (e.g., Caco-2, MDCK) to identify compounds with promising biopharmaceutical properties.

TL;DR: The unique physicochemical properties of PEG are discussed, which make it the polymer of choice to render the surfaces of microparticles repellent to the adsorption of proteins and resistant to cellular recognition.

TL;DR: Casting methods combined with solid free form fabrication are promising for the design of porous network through the manufacturing of 3D scaffolds corresponding to the desired porosity.

TL;DR: An X-ray powder diffraction method coupled with computation of pair distribution functions (PDF) is developed, to more fully assess miscibility in amorphous API-polymer mixture systems.

TL;DR: Aggregation of the antibody during freeze-thawing increased with decreasing pH, which correlated well with Tm values, and was most prevalent at pH 3 and 4, with potential mechanisms involving both the formation of aggregation-prone conformational states as well as adsorption to and denaturation at various interfaces.

TL;DR: The review entails reports on development and characterization of biocompatible microemulsion systems and their evaluation as probable vehicles for encapsulation, stabilization, and delivery of bioactive natural products and prescription drugs.

TL;DR: This review article is a description of the present status of magnetic drug delivery systems, colloidal dispersions of composite nanoparticles consisting of a (polymeric or inorganic) biocompatible matrix and magnetic units, and designed to load and release therapeutic drugs.

TL;DR: It has been demonstrated that the method allows direct pK(a) measurements in aqueous buffers for many compounds of low solubility, often unattainable by other methods.

TL;DR: Mixtures of surfactants, improved dispersion and good oral bioavailability of danazol was evident after administration of formulations comprising CrRH and either Pluronic L121 or Gelucire 44-14, in spite of evidence of danzol precipitation during in vitro digestion of the Gelucires.