M
Masafumi Tsujimoto
Researcher at Teikyo Heisei University
Publications - 83
Citations - 4226
Masafumi Tsujimoto is an academic researcher from Teikyo Heisei University. The author has contributed to research in topics: Aminopeptidase & Tumor necrosis factor alpha. The author has an hindex of 32, co-authored 83 publications receiving 4030 citations. Previous affiliations of Masafumi Tsujimoto include Kyoto University.
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Journal ArticleDOI
Fibroblast Growth Enhancing Activity of Tumor Necrosis Factor and Its Relationship to Other Polypeptide Growth Factors
Jan Vilcek,Vito J. Palombella,D. Henriksen-Destefano,C Swenson,Rena Feinman,M Hirai,Masafumi Tsujimoto +6 more
TL;DR: It is shown that highly purified E. coli-derived recombinant human TNF stimulated the growth of human FS- 4 diploid fibroblasts, and that the cytotoxic and cytostatic actions of TNF may be the result of an anomalous growth signal transduction in neoplastic cells lacking the constraints of normal growth control mechanisms.
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Tumor necrosis factor: specific binding and internalization in sensitive and resistant cells
TL;DR: Results show that resistance of FS-4 cells to TNF cytotoxicity is not due to a lack of receptors or their inability to internalize and degrade TNF, suggesting that degradation occurs intracellularly.
Journal Article
Interferon-gamma enhances expression of cellular receptors for tumor necrosis factor.
TL;DR: Incubation of several human tumor cell lines with human interferon-gamma (IFN-Gamma) increased the specific binding of subsequently added 125I-labeled recombinant human tumor necrosis factor (TNF).
Journal Article
Tumor necrosis factor is an important mediator of tumor cell killing by human monocytes.
TL;DR: TNF is an important mediator of the cytotoxic action of human monocytes for tumor cells and that IFN-gamma can increase monocyte cytotoxicity by sensitizing target cells to the lytic action of TNF.
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Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: role of NF-E2-related factor-2.
Atsuko Sakurai,Michie Nishimoto,Seiichiro Himeno,Seiichiro Himeno,Nobumasa Imura,Masafumi Tsujimoto,Manabu Kunimoto,Shuntaro Hara +7 more
TL;DR: It is shown that cadmium, differently from TNFα, enhanced the promoter activity of the 5′‐flanking region of human TrxR1 gene (nucleotides −1692 to +49) and abolished the response to Cadmium.