M
Masahiko Negishi
Researcher at National Institutes of Health
Publications - 231
Citations - 15710
Masahiko Negishi is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Nuclear receptor & Pregnane X receptor. The author has an hindex of 66, co-authored 225 publications receiving 15019 citations. Previous affiliations of Masahiko Negishi include University of North Carolina at Chapel Hill.
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The nuclear orphan receptor car-retinoid x receptor heterodimer activates the phenobarbital-responsive enhancer module of the cyp2b gene
TL;DR: PBREM was synergistically activated by transfection of CAR and RXR in HepG2 and HEK293 cells when the NR1 site was functional and has thus been characterized as atrans-acting factor for the phenobarbital-inducibleCyp2b10 gene.
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Phenobarbital-Responsive Nuclear Translocation of the Receptor CAR in Induction of the CYP2B Gene
Takeshi Kawamoto,Tatsuya Sueyoshi,Igor Zelko,Rick Moore,Kimberly A. Washburn,Masahiko Negishi +5 more
TL;DR: Both immunoprecipitation and immunohistochemistry studies show cytoplasmic localization of CAR in the livers of nontreated mice, indicating that CAR translocates into nuclei following PB treatment.
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Regulation of cytochrome P450 (CYP) genes by nuclear receptors
TL;DR: This review summarizes recent findings that indicate that major classes of CYP genes are selectively regulated by certain ligand-activated nuclear receptors, thus creating tightly controlled networks.
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Diverse Roles of the Nuclear Orphan Receptor CAR in Regulating Hepatic Genes in Response to Phenobarbital
Akiko Ueda,Hisham K. Hamadeh,Heather K. Webb,Yukio Yamamoto,Tatsuya Sueyoshi,Cynthia A. Afshari,Jürgen M. Lehmann,Masahiko Negishi +7 more
TL;DR: Cyp4a10 and Cyp4a14 represented the group of genes induced by PB only in CAR-null mice, indicating that CAR may be a transcription blocker that prevents these genes from being induced or repressed by PB.
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CAR and PXR: the xenobiotic-sensing receptors.
Yoav E. Timsit,Masahiko Negishi +1 more
TL;DR: The Xenobiotic receptors CAR and PXR as discussed by the authors constitute two important members of the NR1I nuclear receptor family and function as sensors of toxic byproducts derived from endogenous metabolism and of exogenous chemicals, in order to enhance their elimination.