M
Masahiro Taguchi
Researcher at Toyota
Publications - 60
Citations - 437
Masahiro Taguchi is an academic researcher from Toyota. The author has contributed to research in topics: Alkyl & Antibacterial agent. The author has an hindex of 10, co-authored 60 publications receiving 417 citations. Previous affiliations of Masahiro Taguchi include Kyushu University.
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Journal ArticleDOI
Synthesis and antibacterial activity of thiazolo-, oxazolo-, and imidazolo[3,2-a][1,8]naphthyridinecarboxylic acids.
TL;DR: It was found that enhancement of the DNA gyrase inhibitory activity of 3a was dependent on a certain feature of the sulfur atom of the thiazole ring.
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Molecular Design of Boronic Acid-Based Dye Receptors for Nucleosides
TL;DR: Comparison of the complexation constants ofchromophric receptors for nucleosides with those of 2-deoxyadenosine without 2-OH and 1,4-anhydroerythritol without the heteroaromatic ring established that the complex formation is primarily due to the boronic acid–diol (2,3-diol) interaction and secondarily facilitated by the hydrophobic and/or π–π stacking interactions.
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Synthesis and antibacterial activity of thiazolopyrazine-incorporated tetracyclic quinolone antibacterials.
Yoshimasa Inoue,Hirosato Kondo,Masahiro Taguchi,Yoshikazu Jinbo,Fumio Sakamoto,Goro Tsukamoto +5 more
TL;DR: It is significant that these compounds, 5a-q, showed more potent antibacterial activity against methicillin-resistant Staphylococcus aureus isolates (MRSA) than ofloxacin (6), and the combination of the morpholino group and this unique tetracyclic thiazolopyrazine skeleton contributes to the enhancement of the antib bacterial activity against MRSA isolates.
Journal ArticleDOI
Synthesis and Antibacterial Activity of New Tetracyclic Quinolone Antibacterials
Masahiro Taguchi,Hirosato Kondo,Yoshimasa Inoue,Y. Kawahata,Yoshikazu Jinbo,Fumio Sakamoto,Goro Tsukamoto +6 more
TL;DR: A series of 8-substituted-9,1-(epoxymethano)-7-fluoro-5-oxo-5H- thiazolo[3,2-a]quinoline-4-carboxylic acids having a novel tetracyclic structure was synthesized and tested for antibacterial activity, showing the most potent activity against both Gram-positive and Gram-negative bacteria.