Masao Nagao

TL;DR: It is concluded that there is circadian variation of exercise capacity in patients with Prinzmetal's variant angina caused by coronary arterial spasm induced by exercise in the early morning but not in the afternoon.

TL;DR: Long-term prognosis for patients with variant angina is relatively good and that use of calcium antagonists improves it, and multivariate analysis using the Cox proportional hazards model showed that intake of calcium antagonist, extent and severity of coronary artery disease, and ST segment elevation in both the anterior and inferior leads were significant independent predictors of survival without myocardial infarction.

TL;DR: It is concluded that hyperventilation plus Tris-buffer infusion induces coronary arterial spasm and anginal attack in patients with Prinzmetal's variant angina and that diltiazem suppresses these reactions.

TL;DR: It is concluded that coronary arterial spasm can be induced by exercise and can cause exertional angina in some patients and diltiazem and nifedipine, calcium antagonistic drugs, prevent spasm.

TL;DR: Diltiazem and nifedipine, calciumblocking agents, prevent coronary arterial spasm induced by these procedures in almost all patients, but phentolamine, an α-blocking agent, also suppresses coronary arterials spasminduced by these operations in 81% of the patients.