M
Masaomi Miyamoto
Researcher at Johns Hopkins University School of Medicine
Publications - 3
Citations - 1307
Masaomi Miyamoto is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Kainate receptor & Cystine. The author has an hindex of 3, co-authored 3 publications receiving 1238 citations.
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Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress
TL;DR: Glutamate-induced cytotoxicity in N18-RE-105 cells is due to inhibition of cystine uptake, resulting in lowered glutathione levels leading to oxidative stress and cell death.
Journal Article
Antioxidants protect against glutamate-induced cytotoxicity in a neuronal cell line.
TL;DR: Results indicate that oxidative stress due to loss of cellular levels of GSH is one mechanism whereby Glu/quisqualate exert cytotoxicity and suggest that centrally active antioxidants may reduce neuronal damage in pathologic conditions associated with excessive Glu release.
Journal ArticleDOI
Idebenone attenuates neuronal degeneration induced by intrastriatal injection of excitotoxins
Masaomi Miyamoto,Joseph T. Coyle +1 more
TL;DR: The results indicate that treatment with idebenone provides significant protection against the neuronal degeneration induced by intrastriatal injection of kainic acid and quisqualic acid, but not the NMDA receptor agonist, quinolinic acid.