Showing papers in "Experimental Neurology in 1990"

TL;DR: It is demonstrated that KS/CS-PG is inhibitory to embryonic dorsal root ganglia neurites in vitro and that complete inhibition requires contributions from both KS and CS moieties.

TL;DR: Parts of the distribution of BDNF mRNA in the adult pig and rat brain are described, demonstrating that the similarity in structure between NGF and BDNF is paralleled by a similarity in cellular expression, suggesting that BDNF, like NGF, may act via a direct neuron-to-neuron interaction.

TL;DR: Development of layer I and the subplate of the rat neocortex was examined with [3H]thymidine autoradiography and small- to medium-sized horizontal cells in layer I have an extensive period of neurogenesis with an "outside-in" gradient.

TL;DR: The concurrent sprouting of GABAergic terminals in the same IML zone of the FD suggests that anomalous inhibitory synapses may contribute to chronic KA hippocampal hyperexcitability.

TL;DR: The temporal sequence of cellular changes in the denervated zone prior to the observed neural reorganization suggests a role of microglia in astrocyte activation in vivo via production of IL-1 and offers support for a proposed hypothesis postulating a cascade of glial events which may lead to cholinergic sprouting following PP transection.

TL;DR: The results show that an antigen with the correct molecular weight for HLA-DR and the appropriate immunoreactivity for Hla-DR monoclonal antibodies is present in nondemented elderly (ND) and Alzheimer's disease (AD) brain tissue.

TL;DR: The observed developmental patterns of binding to each of the receptor components of the NMDA receptor channel/complex are consistent with postnatal changes in cytoarchitecture, synaptogenesis, afferent lamination, and functional development of the hippocampus.

TL;DR: A hypothesis is presented for the observed abnormal movements suggesting that the CP lesions reduce movement thresholds while the activation of dopaminoceptive regions induces dyskinesias.

TL;DR: It is concluded that some beneficial clinical effects occur, with small to modest changes in most patients and substantial improvement in a minority of patients, but it is not clear that the clinical changes are sufficient to justify performing adrenal medulla transplantation in human patients as a routine procedure.

TL;DR: In dark-exposed animals, Fos-immuno-reactive profiles were distributed throughout the SCN in areas coextensive with the immunohistochemical localization of peptidergic neural elements in both the ventrolateral and dorsomedial subfields.

TL;DR: In the chick embryo retina, Dom induced a lesion pattern having the same distinctive characteristics as a kainic acid lesion which differs from that induced by either NMDA or quisqualate, and the Dom lesion was blocked by CNQX but not by NMDA antagonists.

TL;DR: This paper showed that focal brain injury in mice induced c-fos mRNA and protein in neurons throughout the damaged neocortex, including the piriform and the entorhinal cortices, as well as in non-neural brain cells (e.g., glia, pia, ependyma).

TL;DR: It is proposed that an excitotoxic process mediated by L-DOPA or an acidic derivative such as 6-OH-DPA might be responsible for degeneration of nigral neurons in Parkinson's disease or striatal neurons in Huntington's disease.

TL;DR: The presence of abnormal glial arrangements and glycoconjugate boundaries in the cortices of the genetic mutant mouse reeler, and findings on plasticity of boundaries following various perturbations, suggest that boundary expression is controlled by both genetic and epigenetic factors.

TL;DR: Results from the in vivo investigation show that although chronic levodopa does not significantly affect the number of surviving grafted cells, morphological development of these embryonic DA neurons appears impaired, providing further evidence to support the hypothesis that excess DA or its metabolites can influence the survival and growth of DA neurons.

TL;DR: It is suggested that providing the dorsal root entry zone with an embryonic milieu can stimulate a limited amount of axonal regeneration into the adult mammalian spinal cord.

TL;DR: Neuroanatomical evidence is provided for direct efferent pathways from the A1 noradrenergic cell group to a number of supraspinal sites that have been reliably implicated in the neural circuitry underlying the central regulation of fluid and cardiovascular homeostasis.

TL;DR: The results support a role for overstimulation of a subtype of excitatory amino acid receptor in ischemia-induced cell death and show that the selective sparing of subpopulations of striatal interneurons after ischemic injury is not related to immaturity of these neurons but also occurs in the adult.

TL;DR: Data show that NMDA receptors mediate the induction of Fos and FRAs following cortical injury, and it is proposed that local cortical injury releases excitatory amino acids that act atNMDA receptors to initiate spreading depression and that the resultant depolarization induces Fos in neurons throughout the cortex.

TL;DR: Following a fimbria-fornix lesion, NGF released from polymer matrices effectively prevents a lesion-induced reduction in ChAT expression in basal forebrain neurons.

TL;DR: Application of antibodies or absence of oligodendrocytes during the first postnatal week led to severe anatomical disturbance of the developing rat corticospinal tract, which is known to be followed by abortive sprouting in young rats.

TL;DR: Evidence is accumulating that molecules involved in cell-cell and cell-substratum interactions are important in the establishment and maintenance of borders between cell groups during development, particularly in regard to the role of adhesion molecules in the formation of cell collectives and in the modulation of cell and neurite movements.

TL;DR: It is concluded that the dorsal-anterior sclerotome is permissive and that the perinotochordal mesenchyme is relatively inhibitory for the advance of axons and neural crest cells in the chick embryo.

TL;DR: It is suggested that glucocorticoids influence the rate of hippocampal pyramidal cell disappearance following ischemia, which could be an important adjunct to therapy for preventing ischemic brain damage.

TL;DR: Whether the short-term beneficial effects of nerve growth factor (NGF) upon regeneration are sustained over a prolonged period of time across 8-mm gaps within silicone chambers is examined.

TL;DR: The results suggest that the vulnerability of the hippocampus in temporal lobe epilepsy may result, at least in part, from the presence of aberrant excitatory circuits in the parahippocampal gyrus.

TL;DR: These experiments indicate that astrocytes can respond to signals from a variety of changes in neurons, including not only Wallerian degeneration, but also retrograde and transganglionic changes.

TL;DR: In the present study, in situ hybridization was used to measure levels of messenger ribonucleic acid (mRNA) encoding each of the neurofilament subunits and beta-tubulin in spinal motor neurons at intervals following a unilateral crush of the sciatic nerve.

TL;DR: J1-160 and J1-180 appear to merge into adhesion or stabilization of cell contacts for astrocytes and destabilization of cell interactions or repulsion for neurons, which is likely that these two opposite effects in cell behavior elicited by the J1 molecules result from differential intracellular responses to a cell surface trigger possibly mediated by different cell surface receptors and/or different consequences in intrACEllular signaling networks.

TL;DR: It is concluded that the MPTP-depleted nigrostriatal DA system in aging mouse brain can recover partially following adrenal medullary grafts, but the degree of recovery is more limited compared with that in young brain.