M
Masatsugu Kimura
Researcher at Osaka City University
Publications - 49
Citations - 2501
Masatsugu Kimura is an academic researcher from Osaka City University. The author has contributed to research in topics: Plasmodium falciparum & Population. The author has an hindex of 23, co-authored 49 publications receiving 2386 citations. Previous affiliations of Masatsugu Kimura include Nagoya University.
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Journal ArticleDOI
Artemisinins target the SERCA of Plasmodium falciparum
Ursula Eckstein-Ludwig,Richard Webb,I. D. A. van Goethem,J M East,Anthony G. Lee,Masatsugu Kimura,Paul M. O'Neill,Patrick G. Bray,Stephen A. Ward,Sanjeev Krishna +9 more
TL;DR: It is shown that artemisinins, but not quinine or chloroquine, inhibit the SERCA orthologue (PfATP6) of Plasmodium falciparum in Xenopus oocytes with similar potency to thapsigargin (another sesquiterpene lactone and highly specific SERCA inhibitor).
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Identification of the four species of human malaria parasites by nested PCR that targets variant sequences in the small subunit rRNA gene
Masatsugu Kimura,Osamu Kaneko,Quing Liu,M. Zhou,Fumihiko Kawamoto,Yusuke Wataya,Shuzo Otani,Yoshiko Yamaguchi,Kazuyuki Tanabe +8 more
TL;DR: In this paper, a polymorphic region of the small subunit rRNA gene of the four human malaria parasite species was sequenced to see intraspecies variations and two new variant sequences were found in P. ovale and P. malariae.
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Expression and functional characterization of a Plasmodium falciparum Ca2+-ATPase (PfATP4) belonging to a subclass unique to apicomplexan organisms.
Sanjeev Krishna,Charles J. Woodrow,Richard Webb,Jeffrey Penny,Kunio Takeyasu,Masatsugu Kimura,J. Malcolm East +6 more
TL;DR: This analysis suggests that PfATP4 defines a novel subclass of Ca2+-ATPases unique to apicomplexan organisms and therefore offers potential as a drug target.
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High prevalence of Plasmodium malariae and Plasmodium ovale in malaria patients along the Thai‐Myanmar border, as revealed by acridine orange staining and PCR‐based diagnoses
M. Zhou,Qian Liu,Chansuda Wongsrichanalai,W. Suwonkerd,K. Panart,Somsak Prajakwong,A. Pensiri,Masatsugu Kimura,Hiroyuki Matsuoka,Marcelo U. Ferreira,Shin Isomura,Fumihiko Kawamoto +11 more
TL;DR: Results indicated that the prevalence of P. malariae and P. ovale along the Thai‐Myanmar border may be substantially higher than previously reported.
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Sequence variation in the 18S rRNA gene, a target for PCR-based malaria diagnosis, in Plasmodium ovale from southern Vietnam.
Fumihiko Kawamoto,H Miyake,Osamu Kaneko,Masatsugu Kimura,T D Nguyen,Qian Liu,M. Zhou,D D Le,S Kawai,Shin Isomura,Yusuke Wataya +10 more
TL;DR: Field surveys of malaria were performed in southern Vietnam by using an acridine orange staining method for rapid diagnosis and a PCR-based, microtiter plate hybridization method for accurate diagnosis, which indicated that in addition to molecular biological methods, careful microscopic examination of stained thin blood films is still required in studies of the prevalence of different malaria species.