M
Masihuz Zaman
Researcher at Aligarh Muslim University
Publications - 48
Citations - 1567
Masihuz Zaman is an academic researcher from Aligarh Muslim University. The author has contributed to research in topics: Protein aggregation & Amyloid. The author has an hindex of 20, co-authored 46 publications receiving 1219 citations. Previous affiliations of Masihuz Zaman include Aarhus University.
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Binding of erucic acid with human serum albumin using a spectroscopic and molecular docking study.
Gulam Rabbani,Mohammad Hassan Baig,Arif Tasleem Jan,Eun Ju Lee,Mohsin Vahid Khan,Masihuz Zaman,Abd-ElAziem Farouk,Rizwan Hasan Khan,Inho Choi +8 more
TL;DR: In vitro interaction studies of EA with the primary plasma protein, human serum albumin, reveal a static mode of quenching with binding constant Kb ∼104 reflecting high affinity of EA for HSA and thermodynamic signatures of the HSA-EA interaction in the complex reflect dominance of hydrogen bonds.
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Nanoparticles in relation to peptide and protein aggregation.
TL;DR: The effects of nanoparticles on protein and peptide fibrillation processes are explored from both perspectives (ie, as inducers and inhibitors on nucleation kinetics and in the disaggregation of preformed fibrils).
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Vitamin k3 inhibits protein aggregation: Implication in the treatment of amyloid diseases
Parvez Alam,Sumit Kumar Chaturvedi,Mohammad Khursheed Siddiqi,Ravi Kant Rajpoot,Mohd Rehan Ajmal,Masihuz Zaman,Rizwan Hasan Khan +6 more
TL;DR: It is demonstrated that vitamin k3 significantly inhibits fibril formation as well as the inhibitory effect is dose dependent manner, paving the way for discovery of other small molecules that may exert similar effect against amyloid formation and its associated neurodegenerative diseases.
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Ascorbic acid inhibits human insulin aggregation and protects against amyloid induced cytotoxicity.
Parvez Alam,Ayesha Z. Beg,Mohammad Khursheed Siddiqi,Sumit Kumar Chaturvedi,Ravi Kant Rajpoot,Mohd Rehan Ajmal,Masihuz Zaman,Ali S. Abdelhameed,Rizwan Hasan Khan +8 more
TL;DR: It is demonstrated that ascorbic acid significantly inhibits the fibrillation of HI in a dose-dependent manner and Interestingly ascorBic acid destabilise the preformed amyloid fibrils and protects human neuroblastoma cell line (SH- SY5Y) against amyloids induced cytotoxicity.
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Vitamin B12 offers neuronal cell protection by inhibiting Aβ-42 amyloid fibrillation.
Parvez Alam,Mohammad Khursheed Siddiqi,Sumit Kumar Chaturvedi,Masihuz Zaman,Rizwan Hasan Khan +4 more
TL;DR: It is demonstrated that vitamin B12 (VB), inhibits Aβ- 42 aggregation in a concentration dependent manner and also provide protection against amyloid induced cytotoxicity in human neuronal cell line.