M
Matthew B. Francis
Researcher at Lawrence Berkeley National Laboratory
Publications - 196
Citations - 11640
Matthew B. Francis is an academic researcher from Lawrence Berkeley National Laboratory. The author has contributed to research in topics: Bioconjugation & Chemistry. The author has an hindex of 58, co-authored 182 publications receiving 10260 citations. Previous affiliations of Matthew B. Francis include Harvard University & University of California, Berkeley.
Papers
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Journal ArticleDOI
Choosing an effective protein bioconjugation strategy
TL;DR: The way in which experimental circumstances influence one's selection of an appropriate protein modification strategy is examined and a simple decision tree is provided that can narrow down the possibilities in many instances.
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Dual-surface modification of the tobacco mosaic virus.
TL;DR: The protein shell of the tobacco mosaic virus provides a robust and practical tubelike scaffold for the preparation of nanoscale materials and, through the attachment of PEG polymers to the capsid exterior, organic-soluble TMV rods have been prepared.
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Self-assembling light-harvesting systems from synthetically modified tobacco mosaic virus coat proteins.
TL;DR: Characterization of the system using fluorescence spectroscopy indicated that efficient energy transfer could be achieved from large numbers of donor chromophores to a single acceptor, and energy transfer is proposed to occur through direct donor-acceptor interactions, although degenerate donor-to-donor transfer events are also possible.
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N‐Terminal Protein Modification through a Biomimetic Transamination Reaction
TL;DR: A biomimetic transamination reaction that can modify the N terminus of proteins and peptides under mild conditions and has the potential to introduce virtually any functional group on a wide range of protein substrates.
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Interior Surface Modification of Bacteriophage MS2
TL;DR: An efficient strategy for the interior surface functionalization of MS2 viral capsids is reported, featuring a new hetero-Diels-Alder bioconjugation reaction, which reaches high levels of conversion, and yields the desired conjugates in >60% overall yield.