Showing papers by "Matthew H. Liang published in 2023"
TL;DR: In this article , the authors studied the risk of total hip replacement due to hip osteoarthritis in women and found that the risk is increased with alcohol consumption and the number of hip replacement procedures.
Abstract: Arthritis & RheumatologyAccepted Articles Reply Reply to the Editor: Alcohol consumption and risk of total hip replacement due to hip osteoarthritis in women Nathalie E. Marchand SC.D., Corresponding Author Nathalie E. Marchand SC.D. [email protected] orcid.org/0000-0001-8281-681X Department of Nutrition, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, USACorrespondence: Email: [email protected]Search for more papers by this authorYang Hu SC.D., Yang Hu SC.D. Department of Nutrition, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, USASearch for more papers by this authorMingyang Song M.D., SC.D., Mingyang Song M.D., SC.D. Department of Nutrition, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, USA Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, USA Clinical and Translational Epidemiology Unit and Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MASearch for more papers by this authorBernard A. Rosner PH.D., Bernard A. Rosner PH.D. Department of Biostatistics, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, USA Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USASearch for more papers by this authorElizabeth W. Karlson M.D., Elizabeth W. Karlson M.D. Division of Rheumatology, Inflammation and Immunity, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts, USASearch for more papers by this authorCharles Ratzlaff PH.D., P.T., Charles Ratzlaff PH.D., P.T. Division of Rheumatology, Inflammation and Immunity, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts, USASearch for more papers by this authorBing Lu, Bing Lu Department of Public Health Sciences, University of Connecticut Health Center, Farmington, CT, USASearch for more papers by this authorMatthew H. Liang M.D., M.P.H., Matthew H. Liang M.D., M.P.H. Division of Rheumatology, Inflammation and Immunity, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA Section of Rheumatology, VA Boston Healthcare System, Boston, MA, USASearch for more papers by this authorWalter C. Willett M.D., DR.P.H., Walter C. Willett M.D., DR.P.H. Department of Nutrition, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, USA Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, USA Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USASearch for more papers by this author Nathalie E. Marchand SC.D., Corresponding Author Nathalie E. Marchand SC.D. [email protected] orcid.org/0000-0001-8281-681X Department of Nutrition, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, USACorrespondence: Email: [email protected]Search for more papers by this authorYang Hu SC.D., Yang Hu SC.D. Department of Nutrition, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, USASearch for more papers by this authorMingyang Song M.D., SC.D., Mingyang Song M.D., SC.D. Department of Nutrition, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, USA Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, USA Clinical and Translational Epidemiology Unit and Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MASearch for more papers by this authorBernard A. Rosner PH.D., Bernard A. Rosner PH.D. Department of Biostatistics, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, USA Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USASearch for more papers by this authorElizabeth W. Karlson M.D., Elizabeth W. Karlson M.D. Division of Rheumatology, Inflammation and Immunity, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts, USASearch for more papers by this authorCharles Ratzlaff PH.D., P.T., Charles Ratzlaff PH.D., P.T. Division of Rheumatology, Inflammation and Immunity, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts, USASearch for more papers by this authorBing Lu, Bing Lu Department of Public Health Sciences, University of Connecticut Health Center, Farmington, CT, USASearch for more papers by this authorMatthew H. Liang M.D., M.P.H., Matthew H. Liang M.D., M.P.H. Division of Rheumatology, Inflammation and Immunity, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA Section of Rheumatology, VA Boston Healthcare System, Boston, MA, USASearch for more papers by this authorWalter C. Willett M.D., DR.P.H., Walter C. Willett M.D., DR.P.H. Department of Nutrition, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, USA Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, USA Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USASearch for more papers by this author First published: 22 June 2023 https://doi.org/10.1002/art.42633 This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/art.42633. 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TL;DR: In this paper , the authors examined the relation of alcohol consumption to hip osteoarthritis in women and found that higher alcohol consumption was associated with increased risk of total hip replacement.
Abstract: OBJECTIVE
To examine the relation of alcohol consumption to hip osteoarthritis in women. Alcohol has been associated with both adverse and beneficial health effects generally, however, the relation of alcohol consumption to hip osteoarthritis has been minimally studied.
METHODS
Among women in the Nurses' Health Study cohort in the United States, alcohol consumption was assessed every four years, starting in 1980. Intake was computed as cumulative averages and simple updates with latency periods of 0-4 through 20-24 years. We followed 83,383 women, without diagnosed osteoarthritis in 1988, to June 2012. We identified 1,796 cases of total hip replacement due to hip osteoarthritis, defined by self-report of osteoarthritis with hip replacement.
RESULTS
Alcohol consumption was positively associated with hip osteoarthritis risk. Compared with nondrinkers, multivariable hazard ratios and 95% confidence intervals were 1.04 (0.90, 1.19) for drinkers of >0 to <5 grams/day, 1.12 (0.94, 1.33) for 5 to <10 grams/day, 1.31 (1.10, 1.56) for 10 to <20 grams/day, and 1.34 (1.09, 1.64) for ≥20 grams/day (P trend <0.0001). This association held in latency analyses of up to 16-20 years, and for alcohol consumption between 35-40 years of age. Independent of other alcoholic beverages, the multivariable hazard ratios (per 10 gram of alcohol) were similar for individual types of alcohol intake (wine, liquor, and beer; P heterogeneity among alcohol types = 0.57).
CONCLUSION
Higher alcohol consumption was associated with greater incidence of total hip replacement due to hip osteoarthritis in a dose-dependent manner in women. This article is protected by copyright. All rights reserved.
TL;DR: The CSP590 randomized trial as discussed by the authors was designed to estimate the effect of lithium on suicidality, and only 17% of patients adhered to the specified protocol, and the trial was stopped for futility.
Abstract: Background: The CSP590 randomized trial was designed to estimate the effect of lithium on suicidality. After a third of the intended number of participants were enrolled, the hazard ratio of suicidality was 1.10 (95% CI: 0.77, 1.55). Based on this, the trial was stopped for futility. However, only 17% of patients adhered to the specified protocol. Aims: The objective was to estimate the per-protocol effect of lithium on suicidality, that is, the effect of adhering to the treatment strategies as specified in the protocol. Methods: We stopped individuals’ follow-up if/when they showed evidence of nonadherence. We then conducted the analysis in the restricted sample, adjusting for prognostic factors that predict adherence via inverse probability weighting. The primary outcome was the 12-month risk of suicidality (including death from suicide, suicide attempt, interrupted attempt, hospitalization specifically to prevent suicide). Results: The estimated 12-month risk of suicidality was 18.8% for lithium, and 24.3% for placebo. The risk ratio was 0.78 (95% CI: 0.43, 1.37) and the risk difference −5.5 percentage points (95% CI: −17.5, 5.5). Results were consistent across sensitivity analyses. Conclusions: With one-third of the targeted sample size, lithium effects (compared with placebo) ranging between a 17.5% reduction and a 5.5% increase in the risk of suicidality were highly compatible with the data. Thus, a protective effect of lithium on suicidality among patients with bipolar disorder or major depressive disorder cannot be ruled out. Trials should incorporate adequate per-protocol analyses into the decision-making processes for stopping trials for futility.