M
Matthew J. Comstock
Researcher at Michigan State University
Publications - 44
Citations - 1635
Matthew J. Comstock is an academic researcher from Michigan State University. The author has contributed to research in topics: Femtosecond & RNA. The author has an hindex of 18, co-authored 39 publications receiving 1508 citations. Previous affiliations of Matthew J. Comstock include University of Illinois at Urbana–Champaign & University of California, Berkeley.
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Journal ArticleDOI
Reversible photomechanical switching of individual engineered molecules at a metallic surface.
Matthew J. Comstock,Matthew J. Comstock,Niv Levy,Niv Levy,Armen Kirakosian,Armen Kirakosian,Jongweon Cho,Jongweon Cho,Frank Lauterwasser,Frank Lauterwasser,Jessica H. Harvey,Jessica H. Harvey,David A. Strubbe,David A. Strubbe,Jean M. J. Fréchet,Jean M. J. Fréchet,Dirk Trauner,Dirk Trauner,Steven G. Louie,Steven G. Louie,Michael F. Crommie,Michael F. Crommie +21 more
TL;DR: Scanning tunneling microscopy images show that increasing the number of TB legs "lifts" the azobenzene molecules from the substrate, thereby increasing molecular photomechanical activity by decreasing molecule-surface coupling.
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Ultrahigh-resolution optical trap with single-fluorophore sensitivity
TL;DR: A single-molecule instrument that combines a time-shared ultrahigh-resolution dual optical trap interlaced with a confocal fluorescence microscope will enable the simultaneous measurement of angstrom-scale mechanical motion of individual DNA-binding proteins along with the detection of properties of fluorescently labeled protein.
Journal ArticleDOI
Direct observation of structure-function relationship in a nucleic acid–processing enzyme
Matthew J. Comstock,Kevin D. Whitley,Haifeng Jia,Joshua E. Sokoloski,Timothy M. Lohman,Taekjip Ha,Taekjip Ha,Yann R. Chemla +7 more
TL;DR: A single-molecule technique combining optical tweezers and fluorescence microscopy that allows for both measurements simultaneously of UvrD, a DNA repair helicase, to directly and unambiguously reveal the connection between its structure and function.
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Use of coherent control methods through scattering biological tissue to achieve functional imaging.
TL;DR: The results demonstrate experimentally that the spectral-phase properties of shaped laser pulses optimized to achieve selective two-photon excitation survive as the laser pulses propagate through tissue.
Journal ArticleDOI
Multiphoton intrapulse interference 6; binary phase shaping
TL;DR: A new approach to laser control using binary phase shaping to solve the problem of spectrally narrowing multiphoton excitation using shaped laser pulses as required for selectivity in two-photon microscopy is demonstrated.