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Matthew J. Ovens
Researcher at University of Bristol
Publications - 3
Citations - 415
Matthew J. Ovens is an academic researcher from University of Bristol. The author has contributed to research in topics: Symporter & Lactate transport. The author has an hindex of 3, co-authored 3 publications receiving 330 citations.
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AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7–10
TL;DR: Measurement of the inhibitor sensitivity of several chimaeric transporters combining different domains of MCT1 and MCT4 revealed that the binding site for AR-C155858 is contained within the C-terminal half of M CT1, and involves TM (transmembrane) domains 7–10, consistent with previous data identifying Phe360 and Asp302 plus Arg306 as key residues in substrate binding and translocation by MCT 1.
Journal ArticleDOI
The role of succinate and ROS in reperfusion injury - A critical appraisal.
Tatyana N Andrienko,Philippe Pasdois,Gonçalo C. Pereira,Matthew J. Ovens,Andrew P. Halestrap +4 more
TL;DR: It is concluded that mPTP opening is probably triggered initially by factors other than ROS, including increased mitochondrial [Ca2+], however, IP only attenuates [ Ca2+] increases later in reperfusion, implying that IP regulates mP TP opening through additional mechanisms.
Journal ArticleDOI
The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein
Matthew J. Ovens,Christine Manoharan,Marieangela C. Wilson,Clarey M. Murray,Andrew P. Halestrap +4 more
TL;DR: In mammalian cells, MCTs (monocarboxylate transporters) require association with an ancillary protein to enable plasma membrane expression of the active transporter, and embigin modulates MCT2 sensitivity to AR-C155858 through interactions with both the intracellular C-terminus and TMs 3 and 6 of M CT2.