Matthew Jaffa

TL;DR: It is found that dyslipidemia is not an independent predictor of survival in ALS, and BMI is an independent prognostic factor for survival after adjusting for markers of disease severity.

TL;DR: It is demonstrated that serum uric acid is associated with prolonged survival in ALS, after adjusting for markers of disease severity, and this association was seen in male subjects only.

TL;DR: SOD1 in CSF may be an excellent pharmacodynamic marker for S OD1-lowering therapies because antisense oligonucleotide therapy lowers protein levels in the rat brain and rat CSF samples and because SOD1 levels inCSF samples from humans are stable over time.

TL;DR: The association of longer survival with elevated levels of anti-SODox antibodies suggests that these antibodies may be protective, and implicate aberrantly modified forms of WT-Sod1 (e.g. oxidized SOD1) in SALS pathogenesis.

TL;DR: This work has created one of the largest virtual collections of ALS-related specimens available to investigators studying ALS by developing a secure Web-based system to manage an inventory of multi-site BioRepository.