M
Matthew Martin
Researcher at Robarts Research Institute
Publications - 3
Citations - 969
Matthew Martin is an academic researcher from Robarts Research Institute. The author has contributed to research in topics: Bone marrow & Stem cell. The author has an hindex of 3, co-authored 3 publications receiving 945 citations. Previous affiliations of Matthew Martin include University of Western Ontario.
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Journal ArticleDOI
Bone marrow-derived stem cells initiate pancreatic regeneration.
David A. Hess,Li Li,Matthew Martin,Matthew Martin,Seiji Sakano,David J. Hill,David J. Hill,Brenda Strutt,Sandra Thyssen,Douglas A. Gray,Mickie Bhatia,Mickie Bhatia +11 more
TL;DR: The capacity of transplanted bone marrow–derived stem cells to initiate endogenous pancreatic tissue regeneration represents a previously unrecognized means by which these cells can contribute to the restoration of organ function.
Journal ArticleDOI
Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo.
Barbara Murdoch,Kristin Chadwick,Matthew Martin,Farbod Shojaei,Kavita Shah,Lisa Gallacher,Randall T. Moon,Mickie Bhatia +7 more
TL;DR: In vivo treatment of human repopulating cells with Wnt-5A CM produced a greater proportion of phenotypically primitive hematopoietic progeny that could be isolated and shown to possess enhanced progenitor function independent of continued Wnt -5A treatment, suggesting a potential role for activation of Wnt signaling in managing patients exhibiting poor hematoplastic recovery shortly after stem cell transplantation.
Journal ArticleDOI
Analysis of the human fetal liver hematopoietic microenvironment.
TL;DR: The results suggest that human FL stromal cells provide a unique microenvironment to HSCs compared to adult BM stroma by controlling Wnt signaling of H SCs during human fetal hematopoietic development, while Notch signaling is tightly regulated by the HSC microenvironment in the adult.