Li Li

TL;DR: This study establishes the first evidence for the role of cytokines and BMP-4 in promoting hematopoietic differentiation of hESC lines and provides an unprecedented system to study early developmental events that govern the initiation of hematoiesis in the human.

TL;DR: The capacity of transplanted bone marrow–derived stem cells to initiate endogenous pancreatic tissue regeneration represents a previously unrecognized means by which these cells can contribute to the restoration of organ function.

TL;DR: It is suggested that human hematopoiesis and endothelial maturation originate exclusively from a subset of embryonic endothelium that possesses hemangioblastic properties and offers a model system to study these lineage relationships in the human.

TL;DR: It is demonstrated that hESCs possess unique immune‐privileged characteristics and provides an unprecedented opportunity to further investigate the mechanisms of immune response to transplantation of hESC banks that may avoid immune‐mediated rejection.

TL;DR: It is reported that somatic and hESC-derived hematopoietic cells have similar phenotype and in vitro clonogenic progenitor activity, however, in contrast with somatic cells, hESS-derived HSCs failed to reconstitute intravenously transplanted recipient mice because of cellular aggregation causing fatal emboli formation.