M
Matthew W. Lawless
Researcher at Royal College of Surgeons in Ireland
Publications - 2
Citations - 337
Matthew W. Lawless is an academic researcher from Royal College of Surgeons in Ireland. The author has contributed to research in topics: Unfolded protein response & Endoplasmic reticulum. The author has an hindex of 2, co-authored 2 publications receiving 318 citations.
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Journal ArticleDOI
Activation of endoplasmic reticulum-specific stress responses associated with the conformational disease Z alpha 1-antitrypsin deficiency.
Matthew W. Lawless,Catherine M. Greene,Alan T. Mulgrew,Clifford C. Taggart,Shane J. O'Neill,Noel G. McElvaney +5 more
TL;DR: Interestingly, activation of the unfolded protein response pathway required an additional insult, whereas NF-κB activation, a hallmark of the ER overload response, was constitutive, which has important implications for the design of future therapeutics for Z A1AT liver disease and may also impact on drug design for other conformational diseases.
Journal ArticleDOI
Z α1-Antitrypsin Polymerizes in the Lung and Acts as a Neutrophil Chemoattractant
Alan T. Mulgrew,Clifford C. Taggart,Matthew W. Lawless,Catherine M. Greene,Mark L. Brantly,Shane J. O'Neill,Noel G. McElvaney +6 more
TL;DR: It is suggested that the polymerization of locally produced ZA1AT is a contributory factor to the lung inflammation experienced by those with A1AT deficiency and that standard antiprotease therapies may not address this problem.