Showing papers by "Matthias Breuning published in 2002"

TL;DR: In this paper, the atroposelective synthesis of axially chiral biaryls via configurationally unstable, lactone-bridged biaryl is reviewed, which can be cleaved highly atropo-enantio- or -diastereoselectively by three principal options, either (a) by using a wide range of chiral metalated nucleophiles (usually with external asymmetric induction), or (b) after Lewis acid activation of the lactone CO function using uncharged chiral or achiral nucleoph

TL;DR: The Lactone methodology as discussed by the authors provides directed, atropo-divergent access to any of the two respective atropisomers starting from the identical immediate precursor, a (usually) configurationally unstable, since lactone-bridged biaryl.