Matthias Marczynski

TL;DR: The results challenge the prevailing notion that inert, non-mucoadhesive molecules were always more efficient in penetrating mucin-based hydrogels such as native mucus than charged molecules.

TL;DR: The coating mechanism described here introduces a promising strategy to overcome biofouling issues on a broad range of medical devices and exhibits excellent stability against mechanical, thermal, and chemical challenges.

TL;DR: In this paper, a detailed comparison of commercially available and lab-purified versions of porcine gastric mucins was performed to identify the hydrophobic termini and hydrophilic glycosylation pattern of the mucin glycoprotein.

TL;DR: This manuscript shows that the removal of either sialic acid or sulfate groups from MUC5B drastically reduces its lubricity, and suggests that a loss of anionic sugars mainly influences the dynamic adsorption process of mucins onto both hydrophilic and hydrophobic surfaces.

TL;DR: The results support the notion that the translocation of α-synuclein across mucus barriers observed here might be a critical step in the infection of the gastrointestinal epithelium and the development of Parkinson's disease.