M
Maurits Vandewalle
Researcher at Ghent University
Publications - 104
Citations - 1578
Maurits Vandewalle is an academic researcher from Ghent University. The author has contributed to research in topics: Total synthesis & Ring (chemistry). The author has an hindex of 21, co-authored 104 publications receiving 1533 citations.
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Journal ArticleDOI
1,25-Dihydroxyvitamin D3 and analogues protect primary human keratinocytes against UVB-induced DNA damage.
Petra De Haes,Marjan Garmyn,Marjan Garmyn,Annemieke Verstuyf,Pierre J. De Clercq,Maurits Vandewalle,Hugo Degreef,Katleen Vantieghem,Roger Bouillon,Siegfried Segaert,Siegfried Segaert +10 more
TL;DR: It is demonstrated that 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] protects primary human keratinocytes against the induction of CPDs by UVB and shows that these molecules are promising candidates for the chemoprevention of UVB-induced skin cancer.
Journal ArticleDOI
An Efficient Preparation and the Intramolecular Cyclopropanation of a-Diazo-3-Ketophosphonates and a-Diazophosphonoacetates
TL;DR: In this article, an improved method for the preparation of the title compounds is presented, and several catalysts have been studied for the cyclopropanation reaction; the best results (n = 40-76 %) have been obtained with copper powder in re-fluxing cyclohexane.
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Superagonistic action of 14-epi-analogs of 1,25-dihydroxyvitamin D explained by vitamin D receptor-coactivator interaction.
Guy Eelen,Lieve Verlinden,Natacha Rochel,Frank Claessens,Pierre J. De Clercq,Maurits Vandewalle,Giuseppe D. Tocchini-Valentini,Dino Moras,Roger Bouillon,Annemieke Verstuyf +9 more
TL;DR: This study provides deeper insight into the docking of TX522 in the LBP and shows that stronger VDR-coactivator interactions underlie the superagonistic activity of the two 14-epi-analogs.
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Total synthesis of polycarbocyclic sesquiterpenes: A survey of novel methods and reactions
Journal ArticleDOI
The Biological Activity of Nonsteroidal Vitamin D Hormone Analogs Lacking Both the C- and D-Rings
Annemieke Verstuyf,Lieve Verlinden,Hugo Van Baelen,Katrien Sabbe,Chris D'Hallewyn,Pierre J. De Clercq,Maurits Vandewalle,Roger Bouillon +7 more
TL;DR: These data demonstrate that the full CD‐rings are not mandatory for the biological activity of 1α,25(OH)2D3 since they can be replaced by a new ring structure which generates an appropriate spacing of the A‐seco B‐rings in relation to the side chain.