M
Mauro Niso
Researcher at University of Bari
Publications - 91
Citations - 2214
Mauro Niso is an academic researcher from University of Bari. The author has contributed to research in topics: Receptor & Sigma-2 receptor. The author has an hindex of 28, co-authored 82 publications receiving 1925 citations.
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Journal ArticleDOI
Cyclohexylpiperazine derivative PB28, a σ2 agonist and σ1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer
Amalia Azzariti,Nicola Antonio Colabufo,Francesco Berardi,Letizia Porcelli,Mauro Niso,G.M. Simone,Roberto Perrone,Angelo Paradiso +7 more
TL;DR: It is suggested that the σ2 agonist PB28 could be an interesting antitumor agent either in monotherapy or in combination with conventional drugs.
Journal ArticleDOI
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological, and diagnostic potentials.
Nicola Antonio Colabufo,Francesco Berardi,Mariangela Cantore,Marialessandra Contino,Carmela Inglese,Mauro Niso,Roberto Perrone +6 more
TL;DR: This review will focus on the physiological and pathological role of P-gp and will highlight the involvement of this protein both in MDR of tumors and in the physiological function of several barriers.
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Antiproliferative and cytotoxic effects of some σ2 agonists and σ1 antagonists in tumour cell lines
Nicola Antonio Colabufo,Francesco Berardi,Marialessandra Contino,Mauro Niso,Carmen Abate,Roberto Perrone,Vincenzo Tortorella +6 more
TL;DR: A new model for evaluating both σ2 and σ1 receptor activity of σ ligands is established, which could be useful for developing new ligands having mixed ρ2 agonist/σ1 antagonist activity as potential antineoplastic agents.
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Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives
Nicola Antonio Colabufo,Francesco Berardi,Mariangela Cantore,Maria Grazia Perrone,Marialessandra Contino,Carmela Inglese,Mauro Niso,Roberto Perrone,Amalia Azzariti,G.M. Simone,Letizia Porcelli,Angelo Paradiso +11 more
TL;DR: A new class of small molecules displaying P-gp inhibitor activity differing from reference compounds Elacridar and Tariquidar is suggested for a simplified, and in the meantime, efficacious no-basic moiety.
Journal ArticleDOI
Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents.
Marcello Leopoldo,Francesco Berardi,Nicola Antonio Colabufo,Marialessandra Contino,Enza Lacivita,Mauro Niso,Roberto Perrone,Vincenzo Tortorella +7 more
TL;DR: In relation to 5-HT7 receptor affinity, receptor binding studies indicated that the optimal alkyl chain length was five methylenes, and an unsubstituted 1,2,3,4-tetrahydronaphthalenyl nucleus was preferred, and the substitution pattern of the aryl ring linked to the piperazine ring played a crucial role.