N
Nicola Antonio Colabufo
Researcher at University of Bari
Publications - 201
Citations - 4351
Nicola Antonio Colabufo is an academic researcher from University of Bari. The author has contributed to research in topics: Receptor & P-glycoprotein. The author has an hindex of 35, co-authored 191 publications receiving 3838 citations. Previous affiliations of Nicola Antonio Colabufo include University of Vienna.
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Journal ArticleDOI
Cyclohexylpiperazine derivative PB28, a σ2 agonist and σ1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer
Amalia Azzariti,Nicola Antonio Colabufo,Francesco Berardi,Letizia Porcelli,Mauro Niso,G.M. Simone,Roberto Perrone,Angelo Paradiso +7 more
TL;DR: It is suggested that the σ2 agonist PB28 could be an interesting antitumor agent either in monotherapy or in combination with conventional drugs.
Journal ArticleDOI
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological, and diagnostic potentials.
Nicola Antonio Colabufo,Francesco Berardi,Mariangela Cantore,Marialessandra Contino,Carmela Inglese,Mauro Niso,Roberto Perrone +6 more
TL;DR: This review will focus on the physiological and pathological role of P-gp and will highlight the involvement of this protein both in MDR of tumors and in the physiological function of several barriers.
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Antiproliferative and cytotoxic effects of some σ2 agonists and σ1 antagonists in tumour cell lines
Nicola Antonio Colabufo,Francesco Berardi,Marialessandra Contino,Mauro Niso,Carmen Abate,Roberto Perrone,Vincenzo Tortorella +6 more
TL;DR: A new model for evaluating both σ2 and σ1 receptor activity of σ ligands is established, which could be useful for developing new ligands having mixed ρ2 agonist/σ1 antagonist activity as potential antineoplastic agents.
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Structure-affinity relationship study on N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamides as potent and selective dopamine D3 receptor ligands
Marcello Leopoldo,Francesco Berardi,Nicola Antonio Colabufo,Paola De Giorgio,Enza Lacivita,Roberto Perrone,Vincenzo Tortorella +6 more
TL;DR: Several high-affinity D(3) ligands endowed with high selectivity over D(2), D(4), 5-HT(1A), and alpha(1) receptors are identified.
Journal ArticleDOI
High affinity and selectivity on 5-HT1A receptor of 1-aryl-4-[1-tetralin)alkyl]piperazines. 2.
Roberto Perrone,Francesco Berardi,Nicola Antonio Colabufo,Marcello Leopoldo,Vincenzo Tortorella,Francesco Fiorentini,Vincenzo Olgiati,Alberto Ghiglieri,Stefano Govoni +8 more
TL;DR: Several 4-alkyl-1-arylpiperazines that present a tetralin moiety on the terminal part of the side chain were synthesized in order to increase the selectivity on the 5-HT1A versus D-2, alpha 1, sigma, and other 5- HT receptors.