M
Maury Cole
Researcher at Scripps Research Institute
Publications - 41
Citations - 2896
Maury Cole is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Inhalation & Nicotine. The author has an hindex of 25, co-authored 40 publications receiving 2614 citations.
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Journal ArticleDOI
Decreased brain reward produced by ethanol withdrawal
TL;DR: In this paper, the authors found that increased intracranial self-stimulation (ICSS) reward thresholds also accompany abstinence from chronic ethanol exposure sufficient to induce physical dependence.
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Excessive ethanol drinking following a history of dependence: animal model of allostasis.
TL;DR: Results indicate that operant responding for ethanol was enhanced during protracted abstinence by 30–100% and remained elevated for 4–8 weeks post acute withdrawal, which has important implications for understanding the characteristics and mechanisms underlying vulnerability to relapse.
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Intra-amygdala muscimol decreases operant ethanol self-administration in dependent rats
TL;DR: The data suggest that the reinforcing effects of EtOH and neurotransmitter pathways mediating reward are altered after the development of dependence, and they support the use of this paradigm for further investigations into the neuropharmacological mechanisms mediating reinforcement in dependent versus nondependent animals.
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Increased drinking during withdrawal from intermittent ethanol exposure is blocked by the CRF receptor antagonist D-Phe-CRF(12-41).
Deborah A. Finn,Deborah A. Finn,Christopher Snelling,Andrea M. Fretwell,Michelle A. Tanchuck,Lisa Underwood,Maury Cole,John C. Crabbe,John C. Crabbe,Amanda J. Roberts +9 more
TL;DR: Initial pharmacological studies suggest that manipulation of the CRF system in the CeA can block this increased alcohol intake, and additional behavioral validation and initial pharmacological validation of this withdrawal-associated drinking procedure are provided.
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Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF1 receptor antagonist antalarmin and by CRF1 receptor knockout
TL;DR: These studies, using both a pharmacological and genetic approach, support a critical role for the CRF(1) system in ethanol self-administration following dependence, and a model is presented that may be useful for studies examining underlying mechanisms of the ethanol addiction process as well as for testing potential therapeutics.