Maximo Miko Ondo Obono

TL;DR: Bioko Island possesses a high prevalence of the Pfdhfr triple mutation (CIRNI) and PFDhps single mutation (SGKAA), which will undermine the pharmaceutical effect of SP for malaria treatment strategies, and continuous molecular monitoring and additional control efforts are urgently needed.

TL;DR: The seroprevalence of TTIs varied according to the population from which the blood was collected on Bioko Island, and strict screening of blood donors and improved hematological examinations using standard operating procedures are recommended.

TL;DR: The present data showed high genetic diversity and MOI values among the P. falciparum population in the study, reflecting both the high endemic level and malaria transmission on Bioko Island.

TL;DR: No widespread ART resistance or tolerance in the region is suggested, and this study offers an insight of K13-propeller and PfATPase6 polymorphisms on Bioko Island, EG, which might be helpful for developing and updating guidance for the use of ART-based combination therapies (ACTs).

TL;DR: Investigating the distribution and pattern of multidrug resistance 1 (pfmdr1) gene polymorphisms in P. falciparum isolates collected from the malaria high-endemic Bioko Island, Equatorial Guinea exhibited hypersensitivity to lumefantrine and mefloquine (MQ) and resistance to chloroquine and amodiaquine (AQ).