Mayur V. Bakshi

TL;DR: Details of primers used for quantitative PCR and Reverse Transcriptase PCR Gene symbol Forward strand (5’→3’) Reverse strand ( 5’ →3”) FLK-1.

TL;DR: Radiation-induced endothelial dysfunction was characterized by impaired energy metabolism and perturbation of the insulin/IGF-PI3K-Akt signaling pathway and strongly suggested premature endothelial senescence, increased oxidative stress, decreased NO availability, and enhanced inflammation as main causes of radiation-induced long-term vascular dysfunction.

TL;DR: It is suggested that chronic external radiation enhances the risk for IHD by inhibiting PPAR alpha and altering the expression of mitochondrial, structural, and antioxidant components of the heart.

TL;DR: The authors' data indicate that low and moderate radiation doses induce an immediate inhibition of the glycolysis pathway and pyruvate dehydrogenase availability in the liver and lead to significant long-term alterations in lipid metabolism and increased liver inflammation accompanying inactivation of the transcription factor peroxisome proliferator-activated receptor alpha.

TL;DR: This study indicates that both adaptive and maladaptive responses to the initial radiation damage persist well into adulthood, which will contribute to the understanding of the long-term consequences of radiation-induced injury and developmental alterations in the neonatal heart.