Meenakshi Balganesh

TL;DR: It is shown that these four efflux pump KO mutants of M. tuberculosis play a vital role in mediating efflux of different chemical scaffolds and inhibitors of one or several of these efflux pumps could have a significant impact in the treatment of tuberculosis.

TL;DR: In this paper, the authors have shown that four efflux pumps of Mycobacterium tuberculosis play a vital role in mediating efflux of 48 different chemical scaffolds, and that inhibitors of one or several of these pumps could have a significant impact in the treatment for tuberculosis.

TL;DR: Most of the compound classes had significantly better bactericidal activity in the ΔRv 1218c mutant than in the wild-type H37Rv, suggesting the involvement of Rv1218c gene product in effluxing these compounds from M. tuberculosis.

TL;DR: AZD5847, a novel oxazolidinone, demonstrates improved in vitro bactericidal activity against both extracellular and intracellular M. tuberculosis compared to that of linezolid, and appears to function similarly to lineZolid through impairment of the mycobacterial 50S ribosomal subunit.

TL;DR: Based on pharmacokinetic/pharmacodynamic indexes reported for beta-lactams against other bacterial pathogens, a cumulative percentage of a 24-h period that the drug concentration exceeds the MIC under steady-state pharmacokinetics conditions (%TMIC) of 20 to 40% was achieved in mice using a suitable dosing regimen.