Meenakshi Balganesh

TL;DR: The study indicates that the efflux pump knockout strains are more susceptible to PSI than the wild type, strongly suggesting an important role for efflux pumps in the intrinsic resistance of M. tuberculosis toPSI.

TL;DR: Novel inhibitors in the pyrrolamide class which kill Mycobacterium tuberculosis through inhibition of ATPase activity catalyzed by the GyrB domain of DNA gyrase are identified and could be developed as novel anti-TB agents.

TL;DR: An experimental approach for studying efflux of compounds selected under the More Medicines for Tuberculosis research project is presented, and a few examples of how, for tuberculosis drug discovery, efflux matters are shown.

TL;DR: This Letter describes the synthesis and SAR studies of this class of molecules by variation of two parts of the molecule, the phenyl and triazolopyrimidine rings, and describes optimisation of enzyme potency, whole cell potency and evidence of mechanism of action.

TL;DR: The concentration- dependent killing of streptomycin, the time-dependent killing of ethambutol and the profiling of an experimental anti-mycobacterial compound are shown for the first time by these 2 methods.