M
Melanie A. Lane
Researcher at Mayo Clinic
Publications - 17
Citations - 3414
Melanie A. Lane is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Meta-analysis & Randomized controlled trial. The author has an hindex of 17, co-authored 17 publications receiving 3110 citations. Previous affiliations of Melanie A. Lane include University of Rochester.
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Journal ArticleDOI
Adverse Effects of Testosterone Therapy in Adult Men: A Systematic Review and Meta-Analysis
M. Mercè Fernández-Balsells,Mohammad Hassan Murad,Melanie A. Lane,Juliana F. Lampropulos,Felipe N. Albuquerque,Rebecca J. Mullan,Neera Agrwal,Mohamed B. Elamin,Juan F. Gallegos-Orozco,Amy T. Wang,Patricia J. Erwin,Shalender Bhasin,Victor M. Montori +12 more
TL;DR: The adverse effects of testosterone therapy include an increase in hemoglobin and hematocrit and a small decrease in high-density lipoprotein cholesterol.
Journal ArticleDOI
Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis.
Dirk Bassler,Matthias Briel,Victor M. Montori,Melanie A. Lane,Paul Glasziou,Qi Zhou,Dianne Heels-Ansdell,Stephen D. Walter,Gordon H. Guyatt +8 more
TL;DR: In this paper, the authors compared the treatment effect from truncated RCTs with that from meta-analyses of non-trivial RCT, addressing the same question but not stopping early, and explored factors associated with overestimation of effect.
Journal ArticleDOI
Vitamin D and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis
Mohamed B. Elamin,Nisrin O. Abu Elnour,Khalid B. Elamin,Mitra M. Fatourechi,Aziz A. Alkatib,Jaime P. Almandoz,Hau Liu,Melanie A. Lane,Rebecca J. Mullan,Ahmad Hazem,Patricia J. Erwin,Donald D. Hensrud,Mohammad Hassan Murad,Victor M. Montori +13 more
TL;DR: Trial data available to date are unable to demonstrate a statistically significant reduction in mortality and cardiovascular risk associated with vitamin D, and the quality of the available evidence is low to moderate at best.
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The Effect of Vitamin D on Falls: A Systematic Review and Meta-Analysis
Mohammad Hassan Murad,Khalid B. Elamin,Nisrin O. Abu Elnour,Mohamed B. Elamin,Aziz A. Alkatib,Mitra M. Fatourechi,Jaime P. Almandoz,Rebecca J. Mullan,Melanie A. Lane,Hau Liu,Patricia J. Erwin,Donald D. Hensrud,Victor M. Montori +12 more
TL;DR: Vitamin D use was associated with statistically significant reduction in the risk of falls and was more prominent in patients who were vitamin D deficient at baseline and in studies in which calcium was coadministered with vitamin D.
Journal ArticleDOI
Comparative effectiveness of drug treatments to prevent fragility fractures: A systematic review and network meta-analysis
Mohammad Hassan Murad,Matthew T. Drake,Rebecca J. Mullan,Karen F. Mauck,Louise M. Stuart,Melanie A. Lane,Nisrin O. Abu Elnour,Patricia J. Erwin,Ahmad Hazem,Milo A. Puhan,Tianjing Li,Victor M. Montori +11 more
TL;DR: Differences in efficacy across drugs are small; therefore, patients and clinicians need to consider their associated harms and costs.