M
Melanie E. M. Kelly
Researcher at Dalhousie University
Publications - 108
Citations - 3831
Melanie E. M. Kelly is an academic researcher from Dalhousie University. The author has contributed to research in topics: Cannabinoid receptor & Cannabinoid. The author has an hindex of 34, co-authored 105 publications receiving 3415 citations.
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Journal ArticleDOI
Allosteric and orthosteric pharmacology of cannabidiol and cannabidiol-dimethylheptyl at the type 1 and type 2 cannabinoid receptors.
Mylyne Tham,Orhan Yilmaz,Mariam Alaverdashvili,Melanie E. M. Kelly,Eileen M. Denovan-Wright,Robert B. Laprairie,Robert B. Laprairie +6 more
TL;DR: This work sought to understand why (−)‐cannabidiol (CBD) and (−)-cannABidiol‐dimethylheptyl (C BD‐DMH) exhibit distinct pharmacology, despite near identical structures.
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Carbenoxolone Inhibition of Voltage-Gated Ca Channels and Synaptic Transmission in the Retina
John P. Vessey,Melanie R. Lalonde,Hossein A. Mizan,Nicole C. Welch,Melanie E. M. Kelly,Steven Barnes +5 more
TL;DR: It is shown that carbenoxolone, a drug used to block hemichannels in the retina to test the ephaptic model of horizontal cell inhibitory feedback, has strong inhibitory effects on voltage-gated Ca channels.
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Mitogen-Activated Protein and Tyrosine Kinases in the Activation of Astrocyte Volume-Activated Chloride Current
TL;DR: Activation of tyrosine and MAP kinases by swelling is a critical step in the opening of volume-sensitive Cl− channels in cultured astrocytes, which are thought to be important in regulatory volume decrease and in the response of the CNS to trauma and excitotoxicity.
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Model of endothelin-1-induced chronic optic neuropathy in rat
Balwantray C. Chauhan,Terry L. LeVatte,Christine A. B. Jollimore,Paula K. Yu,Herbert A. Reitsamer,Melanie E. M. Kelly,Dao-Yi Yu,François Tremblay,Michele L. Archibald +8 more
TL;DR: Chronic administration of ET-1 to the rat optic nerve results in a time-dependent loss of RGCs and their axons without apparent change in optic disc topography.
Journal Article
Effect of Intraocular Pressure on Optic Disc Topography, Electroretinography, and Axonal Loss in a Chronic Pressure-Induced Rat Model of Optic Nerve Damage
Balwantray C. Chauhan,Jingyi Pan,Michele L. Archibald,Terry L. LeVatte,Melanie E. M. Kelly,François Tremblay +5 more
TL;DR: Structural and functional changes in this model are best correlated to peak deltaIOP and not to duration of IOP elevation, suggesting the existence of an IOP-related damage threshold.