M
Melanie Lean
Researcher at University College London
Publications - 9
Citations - 344
Melanie Lean is an academic researcher from University College London. The author has contributed to research in topics: Mental health & Randomized controlled trial. The author has an hindex of 7, co-authored 8 publications receiving 207 citations.
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Journal ArticleDOI
Self-management interventions for people with severe mental illness: systematic review and meta-analysis.
Melanie Lean,Miriam Fornells-Ambrojo,Alyssa Milton,Brynmor Lloyd-Evans,Bronwyn Harrison-Stewart,Amina Yesufu-Udechuku,Tim Kendall,Sonia Johnson +7 more
TL;DR: Self-management interventions should form part of the standard package of care provided to people with SMI and should be prioritised in guidelines: research on best methods of implementing such interventions in routine practice is needed.
Journal ArticleDOI
Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression.
Guy M. Goodwin,Scott Aaronson,Oscar Duarte Alvarez,Peter C Arden,Annie Baker,J. Claude Bennett,Catherine Bird,Renske E. Blom,C. Brennan,Donna Brusch,L. Burke,Kete Campbell-Coker,Robin L. Carhart-Harris,Joseph Cattell,Aster Daniel,Charles DeBattista,Boadie W. Dunlop,Katherine Eisen,David Feifel,MacKenzie Forbes,Hannah M Haumann,David J. Hellerstein,Astrid I Hoppe,Muhammad Ishrat Husain,Luke A Jelen,Jeanine Kamphuis,Julie Kawasaki,John R. Kelly,Richard E Key,Ronit Kishon,Stephanie Knatz Peck,Gemma Knight,Martijn H B Koolen,Melanie Lean,Rasmus Wentzer Licht,Jessica L. Maples-Keller,Jan Mars,Lindsey Marwood,Martin McElhiney,Tammy L Miller,Arvin L. Mirow,Sunil Mistry,Tanja Mletzko-Crowe,Liam N Modlin,René Ernst Nielsen,Elizabeth M. Nielson,S.R. Offerhaus,Veronica O'Keane,Tomáš Páleníček,David Printz,Marleen C. Rademaker,Aumer van Reemst,Frederick Reinholdt,Dimitris Repantis,James Rucker,Samuel Rudow,Simon Ruffell,A. John Rush,Robert A. Schoevers,Mathieu Seynaeve,Samantha Shao,Jair C. Soares,Metten Somers,S. C. Stansfield,Diane Sterling,Aaron Strockis,Joyce Tsai,Lucy Visser,Mourad Magdi Wahba,Samuel L. Williams,Allan H. Young,Paula Ywema,Sidney Zisook,E. Malievskaia +73 more
TL;DR: In this paper , a phase 2 trial involving participants with treatment-resistant depression, psilocybin at a single dose of 25 mg, but not 10 mg, reduced depression scores significantly more than a 1-mg dose over a period of 3 weeks but was associated with adverse effects.
Journal ArticleDOI
Service quality and clinical outcomes: an example from mental health rehabilitation services in England
Helen Killaspy,Louise Marston,Rumana Z Omar,Nicholas Green,Isobel Harrison,Melanie Lean,Frank Holloway,Thomas J. Craig,Gerard Leavey,Michael King +9 more
TL;DR: Quality of care is linked to better clinical outcomes in people with complex and longer-term mental health problems, and investing in quality is likely to show real clinical gains.
Journal ArticleDOI
Clinical effectiveness of a staff training intervention in mental health inpatient rehabilitation units designed to increase patients' engagement in activities (the Rehabilitation Effectiveness for Activities for Life [REAL] study): single-blind, cluster-randomised controlled trial
Helen Killaspy,Louise Marston,Nicholas Green,Isobel Harrison,Melanie Lean,Sarah Cook,Timothy Mundy,Tom K. J. Craig,Frank Holloway,Gerard Leavey,Leonardo Koeser,Paul McCrone,Maurice Arbuthnott,Rumana Z Omar,Michael King +14 more
TL;DR: The authors' training intervention did not increase patients' engagement in activities after 12 months of follow-up, which could be attributable to inadequate implementation of the intervention, a high turnover of patients in the intervention units, competing priorities on staff time, high levels of patients' morbidity, and ceiling effects because of the high quality of standard care delivered.
Journal ArticleDOI
Clinical outcomes and costs for people with complex psychosis; a naturalistic prospective cohort study of mental health rehabilitation service users in England
Helen Killaspy,Helen Killaspy,Louise Marston,Nicholas Green,Isobel Harrison,Melanie Lean,Frank Holloway,Tom K. J. Craig,Tom K. J. Craig,Gerard Leavey,Maurice Arbuthnott,Leonardo Koeser,Paul McCrone,Rumana Z Omar,Michael King,Michael King +15 more
TL;DR: Inpatient mental health rehabilitation services in England are able to successfully discharge over half their patients within 18 months, reducing the costs of care for this complex group of patients.